LRRD1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFAP20	CFAP70	ENSP00000262498	ENSP00000310829	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	0.677
CFAP20	DNAI1	ENSP00000262498	ENSP00000480538	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	0.882
CFAP20	DPY30	ENSP00000262498	ENSP00000345837	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family.	0.641
CFAP20	LRRC43	ENSP00000262498	ENSP00000344233	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43.	0.641
CFAP20	LRRD1	ENSP00000262498	ENSP00000405987	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Leucine rich repeats and death domain containing 1.	0.817
CFAP20	MDH1B	ENSP00000262498	ENSP00000363533	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Malate dehydrogenase 1B.	0.632
CFAP20	NME7	ENSP00000262498	ENSP00000356785	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.976
CFAP20	SPACA9	ENSP00000262498	ENSP00000361209	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Sperm acrosome associated 9.	0.893
CFAP20	TEKT1	ENSP00000262498	ENSP00000341346	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family.	0.917
CFAP70	CFAP20	ENSP00000310829	ENSP00000262498	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	0.677
CFAP70	DNAI1	ENSP00000310829	ENSP00000480538	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	0.953
CFAP70	DPY30	ENSP00000310829	ENSP00000345837	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family.	0.707
CFAP70	LRRC43	ENSP00000310829	ENSP00000344233	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43.	0.653
CFAP70	LRRD1	ENSP00000310829	ENSP00000405987	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Leucine rich repeats and death domain containing 1.	0.655
CFAP70	SPACA9	ENSP00000310829	ENSP00000361209	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Sperm acrosome associated 9.	0.641
CFAP70	TEKT1	ENSP00000310829	ENSP00000341346	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family.	0.478
DNAI1	CFAP20	ENSP00000480538	ENSP00000262498	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.	0.882
DNAI1	CFAP70	ENSP00000480538	ENSP00000310829	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	Cilia and flagella associated protein 70; Belongs to the CFAP70 family.	0.953
DNAI1	LRRD1	ENSP00000480538	ENSP00000405987	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	Leucine rich repeats and death domain containing 1.	0.673
DNAI1	MDH1B	ENSP00000480538	ENSP00000363533	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.	Malate dehydrogenase 1B.	0.698