node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACKR1 | CTXN2 | ENSP00000357103 | ENSP00000495988 | Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] | Cortexin-2; Cortexin 2. | 0.461 |
ACKR1 | SLC24A5 | ENSP00000357103 | ENSP00000341550 | Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] | Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. | 0.604 |
ACKR1 | TRPV6 | ENSP00000357103 | ENSP00000352358 | Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] | Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vit [...] | 0.413 |
AMER3 | CTXN2 | ENSP00000392700 | ENSP00000495988 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Cortexin-2; Cortexin 2. | 0.484 |
CDK5R2 | CTXN2 | ENSP00000304250 | ENSP00000495988 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII. | Cortexin-2; Cortexin 2. | 0.436 |
CDK5R2 | RUNDC3A | ENSP00000304250 | ENSP00000410862 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII. | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family. | 0.407 |
CTXN2 | ACKR1 | ENSP00000495988 | ENSP00000357103 | Cortexin-2; Cortexin 2. | Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] | 0.461 |
CTXN2 | AMER3 | ENSP00000495988 | ENSP00000392700 | Cortexin-2; Cortexin 2. | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | 0.484 |
CTXN2 | CDK5R2 | ENSP00000495988 | ENSP00000304250 | Cortexin-2; Cortexin 2. | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII. | 0.436 |
CTXN2 | LRRC55 | ENSP00000495988 | ENSP00000498533 | Cortexin-2; Cortexin 2. | Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. | 0.413 |
CTXN2 | MYEF2 | ENSP00000495988 | ENSP00000316950 | Cortexin-2; Cortexin 2. | Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). | 0.751 |
CTXN2 | NT5DC1 | ENSP00000495988 | ENSP00000326858 | Cortexin-2; Cortexin 2. | 5'-nucleotidase domain containing 1. | 0.444 |
CTXN2 | RUNDC3A | ENSP00000495988 | ENSP00000410862 | Cortexin-2; Cortexin 2. | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family. | 0.419 |
CTXN2 | SLC12A1 | ENSP00000495988 | ENSP00000495332 | Cortexin-2; Cortexin 2. | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | 0.611 |
CTXN2 | SLC24A5 | ENSP00000495988 | ENSP00000341550 | Cortexin-2; Cortexin 2. | Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. | 0.615 |
CTXN2 | TRPV6 | ENSP00000495988 | ENSP00000352358 | Cortexin-2; Cortexin 2. | Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vit [...] | 0.452 |
LRRC55 | CTXN2 | ENSP00000498533 | ENSP00000495988 | Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. | Cortexin-2; Cortexin 2. | 0.413 |
MYEF2 | CTXN2 | ENSP00000316950 | ENSP00000495988 | Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). | Cortexin-2; Cortexin 2. | 0.751 |
MYEF2 | SLC12A1 | ENSP00000316950 | ENSP00000495332 | Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. | 0.504 |
MYEF2 | SLC24A5 | ENSP00000316950 | ENSP00000341550 | Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). | Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. | 0.642 |