node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPW | NT5DC2 | ENSP00000357308 | ENSP00000406933 | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | 5'-nucleotidase domain containing 2. | 0.494 |
CENPW | UBE2T | ENSP00000357308 | ENSP00000494957 | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | 0.667 |
ETFRF1 | NT5DC2 | ENSP00000450584 | ENSP00000406933 | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB); Belongs to the complex I LYR family. | 5'-nucleotidase domain containing 2. | 0.457 |
LRATD1 | NT5DC2 | ENSP00000295092 | ENSP00000406933 | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | 5'-nucleotidase domain containing 2. | 0.461 |
NT5DC2 | CENPW | ENSP00000406933 | ENSP00000357308 | 5'-nucleotidase domain containing 2. | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | 0.494 |
NT5DC2 | ETFRF1 | ENSP00000406933 | ENSP00000450584 | 5'-nucleotidase domain containing 2. | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB); Belongs to the complex I LYR family. | 0.457 |
NT5DC2 | LRATD1 | ENSP00000406933 | ENSP00000295092 | 5'-nucleotidase domain containing 2. | Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family. | 0.461 |
NT5DC2 | NT5DC3 | ENSP00000406933 | ENSP00000376615 | 5'-nucleotidase domain containing 2. | 5'-nucleotidase domain containing 3. | 0.639 |
NT5DC2 | PPM1M | ENSP00000406933 | ENSP00000387046 | 5'-nucleotidase domain containing 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.463 |
NT5DC2 | SMIM4 | ENSP00000406933 | ENSP00000417806 | 5'-nucleotidase domain containing 2. | Small integral membrane protein 4. | 0.512 |
NT5DC2 | STIMATE | ENSP00000406933 | ENSP00000347195 | 5'-nucleotidase domain containing 2. | Store-operated calcium entry regulator STIMATE; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. | 0.510 |
NT5DC2 | TH | ENSP00000406933 | ENSP00000370571 | 5'-nucleotidase domain containing 2. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.443 |
NT5DC2 | UBE2T | ENSP00000406933 | ENSP00000494957 | 5'-nucleotidase domain containing 2. | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | 0.493 |
NT5DC2 | ZNF664 | ENSP00000406933 | ENSP00000441405 | 5'-nucleotidase domain containing 2. | Zinc finger protein 664; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.448 |
NT5DC3 | NT5DC2 | ENSP00000376615 | ENSP00000406933 | 5'-nucleotidase domain containing 3. | 5'-nucleotidase domain containing 2. | 0.639 |
PPM1M | NT5DC2 | ENSP00000387046 | ENSP00000406933 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 5'-nucleotidase domain containing 2. | 0.463 |
SMIM4 | NT5DC2 | ENSP00000417806 | ENSP00000406933 | Small integral membrane protein 4. | 5'-nucleotidase domain containing 2. | 0.512 |
STIMATE | NT5DC2 | ENSP00000347195 | ENSP00000406933 | Store-operated calcium entry regulator STIMATE; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. | 5'-nucleotidase domain containing 2. | 0.510 |
TH | NT5DC2 | ENSP00000370571 | ENSP00000406933 | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 5'-nucleotidase domain containing 2. | 0.443 |
UBE2T | CENPW | ENSP00000494957 | ENSP00000357308 | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] | 0.667 |