node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABTB2 | CKAP5 | ENSP00000410157 | ENSP00000432768 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | 0.410 |
ABTB2 | CUL3 | ENSP00000410157 | ENSP00000264414 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.429 |
ABTB2 | DEPDC7 | ENSP00000410157 | ENSP00000241051 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | DEP domain containing 7; Belongs to the DEPDC7 family. | 0.536 |
ABTB2 | ENSP00000496197 | ENSP00000410157 | ENSP00000496197 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Uncharacterized protein. | 0.526 |
ABTB2 | IFT46 | ENSP00000410157 | ENSP00000264020 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Belongs to the IFT46 family. | 0.440 |
ABTB2 | LRRC42 | ENSP00000410157 | ENSP00000360421 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family. | 0.412 |
ABTB2 | TCP11L1 | ENSP00000410157 | ENSP00000335595 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | T-complex protein 11-like protein 1; T-complex 11 like 1. | 0.406 |
ABTB2 | TTC30B | ENSP00000410157 | ENSP00000386181 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. | 0.417 |
CKAP5 | ABTB2 | ENSP00000432768 | ENSP00000410157 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.410 |
CUL3 | ABTB2 | ENSP00000264414 | ENSP00000410157 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.429 |
DEPDC7 | ABTB2 | ENSP00000241051 | ENSP00000410157 | DEP domain containing 7; Belongs to the DEPDC7 family. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.536 |
DEPDC7 | TCP11L1 | ENSP00000241051 | ENSP00000335595 | DEP domain containing 7; Belongs to the DEPDC7 family. | T-complex protein 11-like protein 1; T-complex 11 like 1. | 0.739 |
ENSP00000496197 | ABTB2 | ENSP00000496197 | ENSP00000410157 | Uncharacterized protein. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.526 |
IFT46 | ABTB2 | ENSP00000264020 | ENSP00000410157 | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Belongs to the IFT46 family. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.440 |
IFT46 | TTC30B | ENSP00000264020 | ENSP00000386181 | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Belongs to the IFT46 family. | Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. | 0.999 |
LRRC42 | ABTB2 | ENSP00000360421 | ENSP00000410157 | Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.412 |
TCP11L1 | ABTB2 | ENSP00000335595 | ENSP00000410157 | T-complex protein 11-like protein 1; T-complex 11 like 1. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.406 |
TCP11L1 | DEPDC7 | ENSP00000335595 | ENSP00000241051 | T-complex protein 11-like protein 1; T-complex 11 like 1. | DEP domain containing 7; Belongs to the DEPDC7 family. | 0.739 |
TTC30B | ABTB2 | ENSP00000386181 | ENSP00000410157 | Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth. | 0.417 |
TTC30B | IFT46 | ENSP00000386181 | ENSP00000264020 | Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Belongs to the IFT46 family. | 0.999 |