ZSCAN2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNBD2	SCAND1	ENSP00000340954	ENSP00000363103	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	SCAN domain-containing protein 1; May regulate transcriptional activity.	0.511
CNBD2	WDR73	ENSP00000340954	ENSP00000387982	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.	0.502
CNBD2	ZSCAN2	ENSP00000340954	ENSP00000410198	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.548
ISY1	TSKU	ENSP00000273541	ENSP00000434847	ISY1 splicing factor homolog.	Tsukushin; Tsukushi, small leucine rich proteoglycan.	0.463
ISY1	XPO7	ENSP00000273541	ENSP00000252512	ISY1 splicing factor homolog.	Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...]	0.457
ISY1	ZSCAN2	ENSP00000273541	ENSP00000410198	ISY1 splicing factor homolog.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.542
NME8	SPATA24	ENSP00000199447	ENSP00000414920	Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.	Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).	0.464
NME8	ZSCAN2	ENSP00000199447	ENSP00000410198	Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.495
PCED1A	ZSCAN2	ENSP00000353868	ENSP00000410198	PC-esterase domain containing 1A; Belongs to the PC-esterase family.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.500
SCAND1	CNBD2	ENSP00000363103	ENSP00000340954	SCAN domain-containing protein 1; May regulate transcriptional activity.	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	0.511
SCAND1	WDR73	ENSP00000363103	ENSP00000387982	SCAN domain-containing protein 1; May regulate transcriptional activity.	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.	0.450
SCAND1	ZSCAN2	ENSP00000363103	ENSP00000410198	SCAN domain-containing protein 1; May regulate transcriptional activity.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.561
SPATA24	NME8	ENSP00000414920	ENSP00000199447	Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).	Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.	0.464
SPATA24	ZSCAN2	ENSP00000414920	ENSP00000410198	Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.543
TDRD3	ZSCAN2	ENSP00000440190	ENSP00000410198	Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.465
TSKU	ISY1	ENSP00000434847	ENSP00000273541	Tsukushin; Tsukushi, small leucine rich proteoglycan.	ISY1 splicing factor homolog.	0.463
TSKU	ZSCAN2	ENSP00000434847	ENSP00000410198	Tsukushin; Tsukushi, small leucine rich proteoglycan.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.460
WDR73	CNBD2	ENSP00000387982	ENSP00000340954	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.	Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	0.502
WDR73	SCAND1	ENSP00000387982	ENSP00000363103	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.	SCAN domain-containing protein 1; May regulate transcriptional activity.	0.450
WDR73	ZSCAN2	ENSP00000387982	ENSP00000410198	WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	0.577