STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CMSS1Protein CMSS1; Cms1 ribosomal small subunit homolog. (279 aa)    
Predicted Functional Partners:
LTV1
Protein LTV1 homolog; LTV1 ribosome biogenesis factor.
   
  
 0.863
NOP53
Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]
   
    0.833
BYSL
Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family.
   
  
 0.746
ZC3H11B
Zinc finger CCCH domain-containing protein 11B; May play a role in mRNA transport.
      
 0.734
UTP23
rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily.
   
   0.729
NIFK
Nucleolar protein interacting with the FHA domain of MKI67.
   
    0.721
ESF1
ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).
   
    0.669
NOL10
Nucleolar protein 10; Belongs to the WD repeat NOL10/ENP2 family.
   
  
 0.654
RBM28
RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes.
   
    0.651
KRR1
KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
   
   0.633
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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