RNF223 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADACL4	H3C1	ENSP00000365395	ENSP00000480826	Arylacetamide deacetylase like 4.	H3 clustered histone 1.	0.434
AADACL4	H3C11	ENSP00000365395	ENSP00000483283	Arylacetamide deacetylase like 4.	H3 clustered histone 11.	0.438
AADACL4	RNF223	ENSP00000365395	ENSP00000410533	Arylacetamide deacetylase like 4.	Ring finger protein 223.	0.662
AADACL4	TIFAB	ENSP00000365395	ENSP00000440509	Arylacetamide deacetylase like 4.	TRAF-interacting protein with FHA domain-containing protein B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.	0.441
AADACL4	TLX2	ENSP00000365395	ENSP00000233638	Arylacetamide deacetylase like 4.	T-cell leukemia homeobox protein 2; Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).	0.418
H3C1	AADACL4	ENSP00000480826	ENSP00000365395	H3 clustered histone 1.	Arylacetamide deacetylase like 4.	0.434
H3C1	H3C11	ENSP00000480826	ENSP00000483283	H3 clustered histone 1.	H3 clustered histone 11.	0.932
H3C1	RNF223	ENSP00000480826	ENSP00000410533	H3 clustered histone 1.	Ring finger protein 223.	0.500
H3C11	AADACL4	ENSP00000483283	ENSP00000365395	H3 clustered histone 11.	Arylacetamide deacetylase like 4.	0.438
H3C11	H3C1	ENSP00000483283	ENSP00000480826	H3 clustered histone 11.	H3 clustered histone 1.	0.932
H3C11	RNF223	ENSP00000483283	ENSP00000410533	H3 clustered histone 11.	Ring finger protein 223.	0.518
KLHL17	RNF223	ENSP00000343930	ENSP00000410533	Kelch-like protein 17; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).	Ring finger protein 223.	0.545
RNF130	RNF223	ENSP00000430237	ENSP00000410533	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.	Ring finger protein 223.	0.512
RNF130	RNFT1	ENSP00000430237	ENSP00000304670	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.	0.463
RNF130	RNFT2	ENSP00000430237	ENSP00000257575	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.	Ring finger protein, transmembrane 2.	0.460
RNF223	AADACL4	ENSP00000410533	ENSP00000365395	Ring finger protein 223.	Arylacetamide deacetylase like 4.	0.662
RNF223	H3C1	ENSP00000410533	ENSP00000480826	Ring finger protein 223.	H3 clustered histone 1.	0.500
RNF223	H3C11	ENSP00000410533	ENSP00000483283	Ring finger protein 223.	H3 clustered histone 11.	0.518
RNF223	KLHL17	ENSP00000410533	ENSP00000343930	Ring finger protein 223.	Kelch-like protein 17; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).	0.545
RNF223	RNF130	ENSP00000410533	ENSP00000430237	Ring finger protein 223.	E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.	0.512