node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GOSR1 | LRCH3 | ENSP00000225724 | ENSP00000399751 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | 0.778 |
GOSR1 | SFT2D2 | ENSP00000225724 | ENSP00000271375 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. | 0.427 |
GOSR1 | ZNF562 | ENSP00000225724 | ENSP00000410734 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.534 |
LRCH3 | GOSR1 | ENSP00000399751 | ENSP00000225724 | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.778 |
LRCH3 | ZNF562 | ENSP00000399751 | ENSP00000410734 | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.534 |
LRRC4B | ZNF562 | ENSP00000498662 | ENSP00000410734 | Leucine-rich repeat-containing protein 4B; Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.481 |
MINDY4B | OR1E2 | ENSP00000491923 | ENSP00000248384 | Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B; MINDY family member 4B; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. | Olfactory receptor 1E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.507 |
MINDY4B | ZNF562 | ENSP00000491923 | ENSP00000410734 | Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B; MINDY family member 4B; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.475 |
OR1E2 | MINDY4B | ENSP00000248384 | ENSP00000491923 | Olfactory receptor 1E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B; MINDY family member 4B; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. | 0.507 |
OR1E2 | ZNF562 | ENSP00000248384 | ENSP00000410734 | Olfactory receptor 1E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.507 |
OR5H14 | ZNF562 | ENSP00000493226 | ENSP00000410734 | Olfactory receptor 5H14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.506 |
SFT2D2 | GOSR1 | ENSP00000271375 | ENSP00000225724 | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.427 |
SFT2D2 | ZNF562 | ENSP00000271375 | ENSP00000410734 | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.465 |
SMARCAD1 | TRIM28 | ENSP00000351947 | ENSP00000253024 | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.998 |
SMARCAD1 | ZNF562 | ENSP00000351947 | ENSP00000410734 | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...] | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.465 |
TRIM28 | SMARCAD1 | ENSP00000253024 | ENSP00000351947 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...] | 0.998 |
TRIM28 | ZNF561 | ENSP00000253024 | ENSP00000303915 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 561; May be involved in transcriptional regulation. | 0.692 |
TRIM28 | ZNF562 | ENSP00000253024 | ENSP00000410734 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.563 |
ZNF561 | TRIM28 | ENSP00000303915 | ENSP00000253024 | Zinc finger protein 561; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.692 |
ZNF561 | ZNF562 | ENSP00000303915 | ENSP00000410734 | Zinc finger protein 561; May be involved in transcriptional regulation. | Zinc finger protein 562; May be involved in transcriptional regulation. | 0.795 |