FAM135A protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD13	ABHD8	ENSP00000365063	ENSP00000247706	Protein ABHD13; Abhydrolase domain containing 13.	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.	0.530
ABHD13	FAM135A	ENSP00000365063	ENSP00000410768	Protein ABHD13; Abhydrolase domain containing 13.	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	0.427
ABHD13	SERAC1	ENSP00000365063	ENSP00000496731	Protein ABHD13; Abhydrolase domain containing 13.	Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.	0.417
ABHD8	ABHD13	ENSP00000247706	ENSP00000365063	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.	Protein ABHD13; Abhydrolase domain containing 13.	0.530
ABHD8	FAM135A	ENSP00000247706	ENSP00000410768	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	0.431
ABHD8	SERAC1	ENSP00000247706	ENSP00000496731	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.	Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.	0.401
AGO2	ANKFY1	ENSP00000220592	ENSP00000459943	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosyn [...]	0.490
AGO2	FAM135A	ENSP00000220592	ENSP00000410768	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	0.471
AGO2	VIRMA	ENSP00000220592	ENSP00000297591	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...]	0.544
ANKFY1	AGO2	ENSP00000459943	ENSP00000220592	Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosyn [...]	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.490
ANKFY1	FAM135A	ENSP00000459943	ENSP00000410768	Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosyn [...]	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	0.402
ANKFY1	VIRMA	ENSP00000459943	ENSP00000297591	Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosyn [...]	Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...]	0.474
ENSP00000497305	FAM135A	ENSP00000497305	ENSP00000410768	Ricin B-type lectin domain-containing protein.	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	0.465
FAM135A	ABHD13	ENSP00000410768	ENSP00000365063	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Protein ABHD13; Abhydrolase domain containing 13.	0.427
FAM135A	ABHD8	ENSP00000410768	ENSP00000247706	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.	0.431
FAM135A	AGO2	ENSP00000410768	ENSP00000220592	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.471
FAM135A	ANKFY1	ENSP00000410768	ENSP00000459943	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosyn [...]	0.402
FAM135A	ENSP00000497305	ENSP00000410768	ENSP00000497305	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Ricin B-type lectin domain-containing protein.	0.465
FAM135A	FAM81A	ENSP00000410768	ENSP00000288228	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Protein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family.	0.428
FAM135A	PLEKHH1	ENSP00000410768	ENSP00000330278	Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.	Pleckstrin homology, MyTH4 and FERM domain containing H1.	0.443