node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK5RAP3 | TSPYL4 | ENSP00000438886 | ENSP00000410943 | CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfold [...] | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.456 |
DFFA | TSPYL4 | ENSP00000366237 | ENSP00000410943 | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40). | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.483 |
GABRD | GABRG2 | ENSP00000367848 | ENSP00000410732 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By si [...] | 0.768 |
GABRD | TSPYL1 | ENSP00000367848 | ENSP00000357597 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 0.444 |
GABRD | TSPYL4 | ENSP00000367848 | ENSP00000410943 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.473 |
GABRG2 | GABRD | ENSP00000410732 | ENSP00000367848 | Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By si [...] | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.768 |
GABRG2 | TSPYL1 | ENSP00000410732 | ENSP00000357597 | Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By si [...] | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 0.423 |
GABRG2 | TSPYL4 | ENSP00000410732 | ENSP00000410943 | Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By si [...] | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.481 |
MAGEA4 | TSPYL1 | ENSP00000353379 | ENSP00000357597 | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 0.488 |
MAGEA4 | TSPYL4 | ENSP00000353379 | ENSP00000410943 | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.610 |
NAP1L3 | TSPYL1 | ENSP00000362171 | ENSP00000357597 | Nucleosome assembly protein 1 like 3. | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 0.442 |
NAP1L3 | TSPYL4 | ENSP00000362171 | ENSP00000410943 | Nucleosome assembly protein 1 like 3. | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.572 |
NAP1L5 | TSPYL4 | ENSP00000320488 | ENSP00000410943 | Nucleosome assembly protein 1 like 5. | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.712 |
NT5DC1 | TSPYL1 | ENSP00000326858 | ENSP00000357597 | 5'-nucleotidase domain containing 1. | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 0.400 |
NT5DC1 | TSPYL4 | ENSP00000326858 | ENSP00000410943 | 5'-nucleotidase domain containing 1. | Testis-specific Y-encoded-like protein 4; TSPY like 4. | 0.518 |
TSPYL1 | GABRD | ENSP00000357597 | ENSP00000367848 | Testis-specific Y-encoded-like protein 1; TSPY like 1. | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | 0.444 |
TSPYL1 | GABRG2 | ENSP00000357597 | ENSP00000410732 | Testis-specific Y-encoded-like protein 1; TSPY like 1. | Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By si [...] | 0.423 |
TSPYL1 | MAGEA4 | ENSP00000357597 | ENSP00000353379 | Testis-specific Y-encoded-like protein 1; TSPY like 1. | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.488 |
TSPYL1 | NAP1L3 | ENSP00000357597 | ENSP00000362171 | Testis-specific Y-encoded-like protein 1; TSPY like 1. | Nucleosome assembly protein 1 like 3. | 0.442 |
TSPYL1 | NT5DC1 | ENSP00000357597 | ENSP00000326858 | Testis-specific Y-encoded-like protein 1; TSPY like 1. | 5'-nucleotidase domain containing 1. | 0.400 |