node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA13 | ABCC9 | ENSP00000411096 | ENSP00000261200 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.528 |
ABCA13 | ABCD4 | ENSP00000411096 | ENSP00000349396 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | 0.579 |
ABCA13 | APOA1 | ENSP00000411096 | ENSP00000236850 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.505 |
ABCA13 | CUX2 | ENSP00000411096 | ENSP00000261726 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | 0.547 |
ABCA13 | DRD4 | ENSP00000411096 | ENSP00000176183 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | D(4) dopamine receptor; Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). | 0.502 |
ABCA13 | FSIP2 | ENSP00000411096 | ENSP00000401306 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. | 0.535 |
ABCA13 | PCLO | ENSP00000411096 | ENSP00000334319 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Protein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). O [...] | 0.527 |
ABCA13 | PHETA1 | ENSP00000411096 | ENSP00000354461 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. | 0.548 |
ABCA13 | SNRNP70 | ENSP00000411096 | ENSP00000472998 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.505 |
ABCA13 | TSPEAR | ENSP00000411096 | ENSP00000321987 | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.530 |
ABCC9 | ABCA13 | ENSP00000261200 | ENSP00000411096 | ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | 0.528 |
ABCC9 | ABCD4 | ENSP00000261200 | ENSP00000349396 | ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | 0.684 |
ABCD4 | ABCA13 | ENSP00000349396 | ENSP00000411096 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | 0.579 |
ABCD4 | ABCC9 | ENSP00000349396 | ENSP00000261200 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. | ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. | 0.684 |
APOA1 | ABCA13 | ENSP00000236850 | ENSP00000411096 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | 0.505 |
CUX2 | ABCA13 | ENSP00000261726 | ENSP00000411096 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily. | 0.547 |
CUX2 | DRD4 | ENSP00000261726 | ENSP00000176183 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | D(4) dopamine receptor; Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). | 0.429 |
CUX2 | PHETA1 | ENSP00000261726 | ENSP00000354461 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. | 0.833 |
CUX2 | SNRNP70 | ENSP00000261726 | ENSP00000472998 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.432 |
CUX2 | TSPEAR | ENSP00000261726 | ENSP00000321987 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence- specific manner. | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.650 |