NPIPB15 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AURKB	KIF14	ENSP00000313950	ENSP00000356319	Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...]	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	0.790
AURKB	NPIPB15	ENSP00000313950	ENSP00000411140	Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...]	Nuclear pore complex interacting protein family member B15.	0.457
EIF2S3B	NPIPB15	ENSP00000323063	ENSP00000411140	Eukaryotic translation initiation factor 2 subunit gamma B.	Nuclear pore complex interacting protein family member B15.	0.503
KIF14	AURKB	ENSP00000356319	ENSP00000313950	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...]	0.790
KIF14	NPIPB15	ENSP00000356319	ENSP00000411140	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	Nuclear pore complex interacting protein family member B15.	0.457
KIF14	NPIPB6	ENSP00000356319	ENSP00000431871	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family.	0.457
NBPF19-2	NPIPB15	ENSP00000478752	ENSP00000411140	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	Nuclear pore complex interacting protein family member B15.	0.428
NBPF26	NPIPB15	ENSP00000481542	ENSP00000411140	Neuroblastoma breakpoint family member 26; NBPF member 26.	Nuclear pore complex interacting protein family member B15.	0.439
NPIPB15	AURKB	ENSP00000411140	ENSP00000313950	Nuclear pore complex interacting protein family member B15.	Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...]	0.457
NPIPB15	EIF2S3B	ENSP00000411140	ENSP00000323063	Nuclear pore complex interacting protein family member B15.	Eukaryotic translation initiation factor 2 subunit gamma B.	0.503
NPIPB15	KIF14	ENSP00000411140	ENSP00000356319	Nuclear pore complex interacting protein family member B15.	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	0.457
NPIPB15	NBPF19-2	ENSP00000411140	ENSP00000478752	Nuclear pore complex interacting protein family member B15.	Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.	0.428
NPIPB15	NBPF26	ENSP00000411140	ENSP00000481542	Nuclear pore complex interacting protein family member B15.	Neuroblastoma breakpoint family member 26; NBPF member 26.	0.439
NPIPB15	NPIPB6	ENSP00000411140	ENSP00000431871	Nuclear pore complex interacting protein family member B15.	Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family.	0.668
NPIPB15	NPIPB7	ENSP00000411140	ENSP00000415207	Nuclear pore complex interacting protein family member B15.	Nuclear pore complex interacting protein family member B7.	0.862
NPIPB15	NPIPB8	ENSP00000411140	ENSP00000434399	Nuclear pore complex interacting protein family member B15.	Nuclear pore complex interacting protein family member B8; Belongs to the NPIP family.	0.862
NPIPB15	NPIPB9	ENSP00000411140	ENSP00000446902	Nuclear pore complex interacting protein family member B15.	Nuclear pore complex interacting protein family member B9; Belongs to the NPIP family.	0.865
NPIPB15	TUBB8B	ENSP00000411140	ENSP00000496713	Nuclear pore complex interacting protein family member B15.	Tubulin beta 8B; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family.	0.441
NPIPB6	KIF14	ENSP00000431871	ENSP00000356319	Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family.	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	0.457
NPIPB6	NPIPB15	ENSP00000431871	ENSP00000411140	Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family.	Nuclear pore complex interacting protein family member B15.	0.668