STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PATE4Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. (98 aa)    
Predicted Functional Partners:
PATE2
Prostate and testis expressed 2.
   
  
 0.826
PATE3
Prostate and testis expressed 3; Belongs to the PATE family.
      
 0.822
PATE1
Prostate and testis expressed 1; Belongs to the PATE family.
      
 0.696
TGM4
Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
      
 0.678
LY6L
Lymphocyte antigen 6 family member L.
      
 0.644
LYNX1
Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and e [...]
      
 0.607
PINLYP
Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family.
   
  
 0.594
SLURP1
Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells may be involved in regulation of intracellular Ca(2+) signaling. Seems to have an immunomodulatory functi [...]
      
 0.591
LYPD4
LY6/PLAUR domain containing 4.
      
 0.588
LYPD5
LY6/PLAUR domain containing 5.
   
  
 0.586
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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