node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSF3 | DHRS12 | ENSP00000479130 | ENSP00000411565 | Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates ; Belongs to the ATP-dependent AMP-binding enzyme family. | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.652 |
ACSF3 | ITPK1 | ENSP00000479130 | ENSP00000267615 | Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates ; Belongs to the ATP-dependent AMP-binding enzyme family. | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] | 0.445 |
DHRS12 | ACSF3 | ENSP00000411565 | ENSP00000479130 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.652 |
DHRS12 | FDX1 | ENSP00000411565 | ENSP00000260270 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | 0.464 |
DHRS12 | ITPK1 | ENSP00000411565 | ENSP00000267615 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] | 0.521 |
DHRS12 | NUDT17 | ENSP00000411565 | ENSP00000334437 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.542 |
DHRS12 | PARVG | ENSP00000411565 | ENSP00000391583 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family. | 0.480 |
DHRS12 | TLCD1 | ENSP00000411565 | ENSP00000292090 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.498 |
DHRS12 | TMCO5A | ENSP00000411565 | ENSP00000327234 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family. | 0.542 |
DHRS12 | TMEM225 | ENSP00000411565 | ENSP00000364166 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. | 0.648 |
DHRS12 | TRAFD1 | ENSP00000411565 | ENSP00000257604 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.512 |
DHRS12 | TRIM69 | ENSP00000411565 | ENSP00000453177 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. | 0.516 |
FDX1 | DHRS12 | ENSP00000260270 | ENSP00000411565 | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.464 |
ITPK1 | ACSF3 | ENSP00000267615 | ENSP00000479130 | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] | Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.445 |
ITPK1 | DHRS12 | ENSP00000267615 | ENSP00000411565 | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.521 |
NUDT17 | DHRS12 | ENSP00000334437 | ENSP00000411565 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.542 |
NUDT17 | TMCO5A | ENSP00000334437 | ENSP00000327234 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family. | 0.539 |
NUDT17 | TMEM225 | ENSP00000334437 | ENSP00000364166 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. | 0.597 |
NUDT17 | TRAFD1 | ENSP00000334437 | ENSP00000257604 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.461 |
PARVG | DHRS12 | ENSP00000391583 | ENSP00000411565 | Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family. | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.480 |