C4orf45 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4orf45	C9orf116	ENSP00000412215	ENSP00000395281	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	0.892
C4orf45	C9orf135	ENSP00000412215	ENSP00000366402	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Protein C9orf135; Chromosome 9 open reading frame 135.	0.890
C4orf45	CCDC105	ENSP00000412215	ENSP00000292574	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Coiled-coil domain containing 105.	0.874
C4orf45	EFHB	ENSP00000412215	ENSP00000295824	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.874
C4orf45	ENKUR	ENSP00000412215	ENSP00000331044	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	0.874
C4orf45	FAM183A	ENSP00000412215	ENSP00000334415	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family.	0.874
C4orf45	NME7	ENSP00000412215	ENSP00000356785	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.874
C4orf45	SPAG8	ENSP00000412215	ENSP00000340982	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.915
C4orf45	TEPP	ENSP00000412215	ENSP00000290871	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Testis, prostate and placenta expressed.	0.874
C4orf45	TEX43	ENSP00000412215	ENSP00000349669	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	Testis-expressed protein 43; Testis expressed 43.	0.874
C9orf116	C4orf45	ENSP00000395281	ENSP00000412215	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.	0.892
C9orf116	C9orf135	ENSP00000395281	ENSP00000366402	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Protein C9orf135; Chromosome 9 open reading frame 135.	0.968
C9orf116	CCDC105	ENSP00000395281	ENSP00000292574	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Coiled-coil domain containing 105.	0.922
C9orf116	EFHB	ENSP00000395281	ENSP00000295824	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.974
C9orf116	ENKUR	ENSP00000395281	ENSP00000331044	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	0.974
C9orf116	FAM183A	ENSP00000395281	ENSP00000334415	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family.	0.957
C9orf116	NME7	ENSP00000395281	ENSP00000356785	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.971
C9orf116	SPAG8	ENSP00000395281	ENSP00000340982	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.911
C9orf116	TEPP	ENSP00000395281	ENSP00000290871	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Testis, prostate and placenta expressed.	0.895
C9orf116	TEX43	ENSP00000395281	ENSP00000349669	UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.	Testis-expressed protein 43; Testis expressed 43.	0.915