MALRD1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRG4	DGAT2L6	ENSP00000377699	ENSP00000328036	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	0.443
ADGRG4	LSMEM1	ENSP00000377699	ENSP00000323304	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Leucine rich single-pass membrane protein 1.	0.435
ADGRG4	MALRD1	ENSP00000377699	ENSP00000412763	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	0.467
CLIP3	MALRD1	ENSP00000353732	ENSP00000412763	CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	0.446
DGAT2L6	ADGRG4	ENSP00000328036	ENSP00000377699	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	0.443
DGAT2L6	LSMEM1	ENSP00000328036	ENSP00000323304	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	Leucine rich single-pass membrane protein 1.	0.470
DGAT2L6	MALRD1	ENSP00000328036	ENSP00000412763	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	0.434
LSMEM1	ADGRG4	ENSP00000323304	ENSP00000377699	Leucine rich single-pass membrane protein 1.	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	0.435
LSMEM1	DGAT2L6	ENSP00000323304	ENSP00000328036	Leucine rich single-pass membrane protein 1.	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	0.470
LSMEM1	MALRD1	ENSP00000323304	ENSP00000412763	Leucine rich single-pass membrane protein 1.	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	0.404
MALRD1	ADGRG4	ENSP00000412763	ENSP00000377699	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	0.467
MALRD1	CLIP3	ENSP00000412763	ENSP00000353732	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.	0.446
MALRD1	DGAT2L6	ENSP00000412763	ENSP00000328036	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters ; Belongs to the diacylglycerol acyltransferase family.	0.434
MALRD1	LSMEM1	ENSP00000412763	ENSP00000323304	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Leucine rich single-pass membrane protein 1.	0.404
MALRD1	MAPKBP1	ENSP00000412763	ENSP00000393099	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway (By similarity).	0.463
MALRD1	PLXDC2	ENSP00000412763	ENSP00000366460	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family.	0.461
MALRD1	RABL2A	ENSP00000412763	ENSP00000387229	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.	0.450
MALRD1	ZBTB7C	ENSP00000412763	ENSP00000468782	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	Zinc finger and BTB domain-containing protein 7C; May be a tumor suppressor gene.	0.442
MAPKBP1	MALRD1	ENSP00000393099	ENSP00000412763	Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway (By similarity).	MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	0.463
MAPKBP1	RABL2A	ENSP00000393099	ENSP00000387229	Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway (By similarity).	Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.	0.423