STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF805Zinc finger protein 805; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (627 aa)    
Predicted Functional Partners:
ZNF264
Zinc finger protein 264; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
0.715
KLHL11
Kelch-like protein 11; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
   
    0.560
KATNBL1
KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.
      
 0.509
C2CD2
C2 calcium dependent domain containing 2.
      
 0.505
INTS2
Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
   
  
 0.499
SLC25A51
Solute carrier family 25 member 51.
   
 
 0.463
N4BP2L2
NEDD4 binding protein 2 like 2.
      
 0.463
THEM5
Acyl-coenzyme A thioesterase THEM5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.
      
 0.460
TRAPPC1
Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily.
      
 0.436
GTF2IRD2B
General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family.
      
 0.434
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.