C16orf91 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	C16orf91	ENSP00000220592	ENSP00000413100	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein CCSMST1; Chromosome 16 open reading frame 91.	0.457
AGO2	C18orf21	ENSP00000220592	ENSP00000465517	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	0.841
C11orf42	C16orf91	ENSP00000321021	ENSP00000413100	Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42.	Protein CCSMST1; Chromosome 16 open reading frame 91.	0.600
C11orf42	C18orf21	ENSP00000321021	ENSP00000465517	Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42.	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	0.495
C12orf73	C16orf91	ENSP00000367330	ENSP00000413100	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	Protein CCSMST1; Chromosome 16 open reading frame 91.	0.400
C12orf73	UQCC1	ENSP00000367330	ENSP00000363506	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.	0.895
C12orf73	UQCC2	ENSP00000367330	ENSP00000476140	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.	0.856
C15orf61	C16orf91	ENSP00000342254	ENSP00000413100	Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61.	Protein CCSMST1; Chromosome 16 open reading frame 91.	0.458
C16orf91	AGO2	ENSP00000413100	ENSP00000220592	Protein CCSMST1; Chromosome 16 open reading frame 91.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.457
C16orf91	C11orf42	ENSP00000413100	ENSP00000321021	Protein CCSMST1; Chromosome 16 open reading frame 91.	Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42.	0.600
C16orf91	C12orf73	ENSP00000413100	ENSP00000367330	Protein CCSMST1; Chromosome 16 open reading frame 91.	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	0.400
C16orf91	C15orf61	ENSP00000413100	ENSP00000342254	Protein CCSMST1; Chromosome 16 open reading frame 91.	Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61.	0.458
C16orf91	C18orf21	ENSP00000413100	ENSP00000465517	Protein CCSMST1; Chromosome 16 open reading frame 91.	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	0.592
C16orf91	COX20	ENSP00000413100	ENSP00000355486	Protein CCSMST1; Chromosome 16 open reading frame 91.	Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme.	0.968
C16orf91	GKN1	ENSP00000413100	ENSP00000501093	Protein CCSMST1; Chromosome 16 open reading frame 91.	Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.	0.462
C16orf91	GKN2	ENSP00000413100	ENSP00000329292	Protein CCSMST1; Chromosome 16 open reading frame 91.	Gastrokine-2; Gastrokine 2.	0.476
C16orf91	UQCC1	ENSP00000413100	ENSP00000363506	Protein CCSMST1; Chromosome 16 open reading frame 91.	Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.	0.400
C16orf91	UQCC2	ENSP00000413100	ENSP00000476140	Protein CCSMST1; Chromosome 16 open reading frame 91.	Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.	0.896
C18orf21	AGO2	ENSP00000465517	ENSP00000220592	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.841
C18orf21	C11orf42	ENSP00000465517	ENSP00000321021	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42.	0.495