node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMER3 | TMEM130 | ENSP00000392700 | ENSP00000413163 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Transmembrane protein 130. | 0.405 |
AMER3 | TMEM145 | ENSP00000392700 | ENSP00000301204 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Transmembrane protein 145. | 0.477 |
AMER3 | TMEM179 | ENSP00000392700 | ENSP00000450958 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Transmembrane protein 179; Belongs to the TMEM179 family. | 0.450 |
AMER3 | TMEM88B | ENSP00000392700 | ENSP00000455099 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | Transmembrane protein 88B. | 0.431 |
B3GALT2 | TMEM130 | ENSP00000356404 | ENSP00000413163 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N- acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha- GalNAc) residues. | Transmembrane protein 130. | 0.446 |
DIRAS2 | TMEM130 | ENSP00000364919 | ENSP00000413163 | GTP-binding protein Di-Ras2; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family. | Transmembrane protein 130. | 0.410 |
ERMN | TMEM130 | ENSP00000380453 | ENSP00000413163 | Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). | Transmembrane protein 130. | 0.561 |
FRRS1L | TMEM130 | ENSP00000477141 | ENSP00000413163 | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | Transmembrane protein 130. | 0.520 |
TMEM130 | AMER3 | ENSP00000413163 | ENSP00000392700 | Transmembrane protein 130. | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | 0.405 |
TMEM130 | B3GALT2 | ENSP00000413163 | ENSP00000356404 | Transmembrane protein 130. | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N- acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha- GalNAc) residues. | 0.446 |
TMEM130 | DIRAS2 | ENSP00000413163 | ENSP00000364919 | Transmembrane protein 130. | GTP-binding protein Di-Ras2; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family. | 0.410 |
TMEM130 | ERMN | ENSP00000413163 | ENSP00000380453 | Transmembrane protein 130. | Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). | 0.561 |
TMEM130 | FRRS1L | ENSP00000413163 | ENSP00000477141 | Transmembrane protein 130. | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | 0.520 |
TMEM130 | TMEM145 | ENSP00000413163 | ENSP00000301204 | Transmembrane protein 130. | Transmembrane protein 145. | 0.471 |
TMEM130 | TMEM179 | ENSP00000413163 | ENSP00000450958 | Transmembrane protein 130. | Transmembrane protein 179; Belongs to the TMEM179 family. | 0.424 |
TMEM130 | TMEM88B | ENSP00000413163 | ENSP00000455099 | Transmembrane protein 130. | Transmembrane protein 88B. | 0.421 |
TMEM130 | UBE2QL1 | ENSP00000413163 | ENSP00000382713 | Transmembrane protein 130. | Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7; Belongs to the ubiquitin-conjugating enzyme family. | 0.510 |
TMEM130 | UNC80 | ENSP00000413163 | ENSP00000391088 | Transmembrane protein 130. | Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN- dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium. | 0.428 |
TMEM145 | AMER3 | ENSP00000301204 | ENSP00000392700 | Transmembrane protein 145. | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). | 0.477 |
TMEM145 | TMEM130 | ENSP00000301204 | ENSP00000413163 | Transmembrane protein 145. | Transmembrane protein 130. | 0.471 |