STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF492Zinc finger protein 492; May be involved in transcriptional regulation; Zinc fingers C2H2-type (531 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
   
 0.904
ANKRD20A4
Ankyrin repeat domain-containing protein 20A4; Ankyrin repeat domain 20 family member A4
   
 
 0.672
ANKRD20A2
Ankyrin repeat domain-containing protein 20A2; Ankyrin repeat domain 20 family member A2
   
 
 0.672
CBWD7
COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily
      
 0.641
FAM72C
Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family
      
 0.595
C11orf40
Putative uncharacterized protein C11orf40; Chromosome 11 open reading frame 40
      
 0.580
KRTAP19-2
Keratin-associated protein 19-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins
      
 0.570
OR13A1
Olfactory receptor 13A1; Odorant receptor; Olfactory receptors, family 13
      
 0.570
SATL1
Spermidine/spermine N1-acetyl transferase like 1; GCN5 related N-acetyltransferases
      
 0.544
FAM182B
Protein FAM182B; Family with sequence similarity 182 member B
      
 0.541
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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