| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARPP19 | HSBP1L1 | ENSP00000454341 | ENSP00000414236 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | 0.497 |
| ARPP19 | SMS | ENSP00000454341 | ENSP00000385746 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.415 |
| ARPP19 | STOML2 | ENSP00000454341 | ENSP00000348886 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] | 0.466 |
| CARS2 | HSBP1L1 | ENSP00000257347 | ENSP00000414236 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | 0.476 |
| CARS2 | IREB2 | ENSP00000257347 | ENSP00000258886 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.520 |
| HSBP1L1 | ARPP19 | ENSP00000414236 | ENSP00000454341 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | 0.497 |
| HSBP1L1 | CARS2 | ENSP00000414236 | ENSP00000257347 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.476 |
| HSBP1L1 | HSPA4 | ENSP00000414236 | ENSP00000302961 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.639 |
| HSBP1L1 | IREB2 | ENSP00000414236 | ENSP00000258886 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.477 |
| HSBP1L1 | RBFA | ENSP00000414236 | ENSP00000305696 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | 0.473 |
| HSBP1L1 | SLC66A2 | ENSP00000414236 | ENSP00000380880 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Solute carrier family 66 member 2. | 0.509 |
| HSBP1L1 | SMS | ENSP00000414236 | ENSP00000385746 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.488 |
| HSBP1L1 | STOML2 | ENSP00000414236 | ENSP00000348886 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] | 0.498 |
| HSBP1L1 | TRMO | ENSP00000414236 | ENSP00000364260 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity). | 0.699 |
| HSBP1L1 | TXNL4A | ENSP00000414236 | ENSP00000269601 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | Thioredoxin-like protein 4A; Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex); Belongs to the DIM1 family. | 0.491 |
| HSPA4 | HSBP1L1 | ENSP00000302961 | ENSP00000414236 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | 0.639 |
| IREB2 | CARS2 | ENSP00000258886 | ENSP00000257347 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.520 |
| IREB2 | HSBP1L1 | ENSP00000258886 | ENSP00000414236 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | 0.477 |
| RBFA | HSBP1L1 | ENSP00000305696 | ENSP00000414236 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family. | 0.473 |
| RBFA | SLC66A2 | ENSP00000305696 | ENSP00000380880 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | Solute carrier family 66 member 2. | 0.632 |
