EFCC1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf198	EFCC1	ENSP00000355623	ENSP00000414597	Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198.	EF-hand and coiled-coil domain containing 1.	0.446
EFCAB11	EFCC1	ENSP00000326267	ENSP00000414597	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	EF-hand and coiled-coil domain containing 1.	0.445
EFCC1	C1orf198	ENSP00000414597	ENSP00000355623	EF-hand and coiled-coil domain containing 1.	Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198.	0.446
EFCC1	EFCAB11	ENSP00000414597	ENSP00000326267	EF-hand and coiled-coil domain containing 1.	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.445
EFCC1	ERMN	ENSP00000414597	ENSP00000380453	EF-hand and coiled-coil domain containing 1.	Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).	0.465
EFCC1	HDHD5	ENSP00000414597	ENSP00000337358	EF-hand and coiled-coil domain containing 1.	Haloacid dehalogenase like hydrolase domain containing 5.	0.443
EFCC1	ISY1	ENSP00000414597	ENSP00000273541	EF-hand and coiled-coil domain containing 1.	ISY1 splicing factor homolog.	0.532
EFCC1	ISY1-RAB43	ENSP00000414597	ENSP00000411822	EF-hand and coiled-coil domain containing 1.	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenes [...]	0.490
EFCC1	LYPD6	ENSP00000414597	ENSP00000334463	EF-hand and coiled-coil domain containing 1.	Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).	0.444
EFCC1	PET100	ENSP00000414597	ENSP00000470539	EF-hand and coiled-coil domain containing 1.	Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family.	0.496
EFCC1	PFDN4	ENSP00000414597	ENSP00000360473	EF-hand and coiled-coil domain containing 1.	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	0.448
EFCC1	POLR2K	ENSP00000414597	ENSP00000342889	EF-hand and coiled-coil domain containing 1.	DNA-directed RNA polymerases I, II, and III subunit RPABC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.	0.462
ERMN	EFCC1	ENSP00000380453	ENSP00000414597	Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).	EF-hand and coiled-coil domain containing 1.	0.465
HDHD5	EFCC1	ENSP00000337358	ENSP00000414597	Haloacid dehalogenase like hydrolase domain containing 5.	EF-hand and coiled-coil domain containing 1.	0.443
HDHD5	ISY1	ENSP00000337358	ENSP00000273541	Haloacid dehalogenase like hydrolase domain containing 5.	ISY1 splicing factor homolog.	0.737
HDHD5	ISY1-RAB43	ENSP00000337358	ENSP00000411822	Haloacid dehalogenase like hydrolase domain containing 5.	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenes [...]	0.692
ISY1	EFCC1	ENSP00000273541	ENSP00000414597	ISY1 splicing factor homolog.	EF-hand and coiled-coil domain containing 1.	0.532
ISY1	HDHD5	ENSP00000273541	ENSP00000337358	ISY1 splicing factor homolog.	Haloacid dehalogenase like hydrolase domain containing 5.	0.737
ISY1	ISY1-RAB43	ENSP00000273541	ENSP00000411822	ISY1 splicing factor homolog.	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenes [...]	0.808
ISY1-RAB43	EFCC1	ENSP00000411822	ENSP00000414597	Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenes [...]	EF-hand and coiled-coil domain containing 1.	0.490