STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRRC34Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. (464 aa)    
Predicted Functional Partners:
MYNN
Myoneurin.
   
  
 0.810
LRRIQ4
Leucine rich repeats and IQ motif containing 4.
      
 0.730
ACTRT3
Actin related protein T3.
   
 
 0.700
LRRC31
Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31.
 
    
 0.652
LRRC23
Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.
   
  
 0.619
INSYN2B
Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family.
   
 
 0.607
CCDC146
Coiled-coil domain containing 146.
   
  
 0.577
RSPH14
Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family.
   
 
 0.569
CFAP161
Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.
   
  
 0.550
TSNAXIP1
Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis.
   
  
 0.520
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.