CFAP97D1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK8	C17orf98	ENSP00000298545	ENSP00000479396	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.632
AK8	C5orf49	ENSP00000298545	ENSP00000382708	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.	0.632
AK8	C9orf135	ENSP00000298545	ENSP00000366402	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Protein C9orf135; Chromosome 9 open reading frame 135.	0.740
AK8	CCDC65	ENSP00000298545	ENSP00000312706	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family.	0.694
AK8	CFAP161	ENSP00000298545	ENSP00000286732	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.	0.719
AK8	CFAP97D1	ENSP00000298545	ENSP00000415662	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	0.734
AK8	DNAH10	ENSP00000298545	ENSP00000489675	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.	0.909
AK8	IQUB	ENSP00000298545	ENSP00000417769	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance.	0.764
AK8	SPAG8	ENSP00000298545	ENSP00000340982	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.877
C10orf82	C17orf98	ENSP00000465712	ENSP00000479396	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.689
C10orf82	C5orf49	ENSP00000465712	ENSP00000382708	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.	0.856
C10orf82	C9orf135	ENSP00000465712	ENSP00000366402	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Protein C9orf135; Chromosome 9 open reading frame 135.	0.914
C10orf82	CFAP161	ENSP00000465712	ENSP00000286732	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.	0.869
C10orf82	CFAP97D1	ENSP00000465712	ENSP00000415662	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	0.697
C10orf82	SPAG8	ENSP00000465712	ENSP00000340982	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.883
C17orf98	AK8	ENSP00000479396	ENSP00000298545	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	0.632
C17orf98	C10orf82	ENSP00000479396	ENSP00000465712	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	0.689
C17orf98	C5orf49	ENSP00000479396	ENSP00000382708	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.	0.699
C17orf98	C9orf135	ENSP00000479396	ENSP00000366402	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Protein C9orf135; Chromosome 9 open reading frame 135.	0.742
C17orf98	CCDC65	ENSP00000479396	ENSP00000312706	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family.	0.632