node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD48 | PRAP1 | ENSP00000484431 | ENSP00000416126 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.717 |
FUOM | PRAP1 | ENSP00000278025 | ENSP00000416126 | Fucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.496 |
IGHV3OR16-9 | PRAP1 | ENSP00000475107 | ENSP00000416126 | Immunoglobulin heavy variable 3/OR16-9. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.402 |
LACRT | PRAP1 | ENSP00000257867 | ENSP00000416126 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.454 |
LZTS3 | PRAP1 | ENSP00000353496 | ENSP00000416126 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.464 |
LZTS3 | RPP40 | ENSP00000353496 | ENSP00000369391 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | 0.490 |
NPL | PRAP1 | ENSP00000258317 | ENSP00000416126 | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.405 |
PLA2G12B | PRAP1 | ENSP00000362123 | ENSP00000416126 | Group XIIB secretory phospholipase A2-like protein; Not known; does not seem to have catalytic activity. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.431 |
PRAP1 | CD48 | ENSP00000416126 | ENSP00000484431 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | 0.717 |
PRAP1 | FUOM | ENSP00000416126 | ENSP00000278025 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Fucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. | 0.496 |
PRAP1 | IGHV3OR16-9 | ENSP00000416126 | ENSP00000475107 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Immunoglobulin heavy variable 3/OR16-9. | 0.402 |
PRAP1 | LACRT | ENSP00000416126 | ENSP00000257867 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells. | 0.454 |
PRAP1 | LZTS3 | ENSP00000416126 | ENSP00000353496 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family. | 0.464 |
PRAP1 | NPL | ENSP00000416126 | ENSP00000258317 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity). | 0.405 |
PRAP1 | PLA2G12B | ENSP00000416126 | ENSP00000362123 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Group XIIB secretory phospholipase A2-like protein; Not known; does not seem to have catalytic activity. | 0.431 |
PRAP1 | RPL37A | ENSP00000416126 | ENSP00000418082 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Ribosomal protein L37a. | 0.401 |
PRAP1 | RPP40 | ENSP00000416126 | ENSP00000369391 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | 0.470 |
PRAP1 | TMEM184B | ENSP00000416126 | ENSP00000354441 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.458 |
RPL37A | PRAP1 | ENSP00000418082 | ENSP00000416126 | Ribosomal protein L37a. | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells. | 0.401 |
RPL37A | TMEM184B | ENSP00000418082 | ENSP00000354441 | Ribosomal protein L37a. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.406 |