WDR27 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNS	WDR27	ENSP00000377845	ENSP00000416289	Asparagine synthetase.	WD repeat domain 27.	0.571
C6orf120	ERMARD	ENSP00000346931	ENSP00000355735	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	0.615
C6orf120	PHF10	ENSP00000346931	ENSP00000341805	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...]	0.639
C6orf120	TCTE3	ENSP00000346931	ENSP00000355736	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein light chain Tctex-type family.	0.667
C6orf120	WDR27	ENSP00000346931	ENSP00000416289	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	WD repeat domain 27.	0.724
CDCP2	WDR27	ENSP00000489959	ENSP00000416289	CUB domain containing protein 2.	WD repeat domain 27.	0.502
CXorf56	WDR27	ENSP00000441786	ENSP00000416289	UPF0428 protein CXorf56; Chromosome X open reading frame 56.	WD repeat domain 27.	0.580
ERMARD	C6orf120	ENSP00000355735	ENSP00000346931	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	0.615
ERMARD	FAM120B	ENSP00000355735	ENSP00000440125	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); Belongs to the constitutive coactivator of PPAR-gamma family.	0.551
ERMARD	PHF10	ENSP00000355735	ENSP00000341805	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...]	0.658
ERMARD	TCTE3	ENSP00000355735	ENSP00000355736	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein light chain Tctex-type family.	0.660
ERMARD	WDR27	ENSP00000355735	ENSP00000416289	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	WD repeat domain 27.	0.644
FAM120B	ERMARD	ENSP00000440125	ENSP00000355735	Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); Belongs to the constitutive coactivator of PPAR-gamma family.	Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.	0.551
FAM120B	PHF10	ENSP00000440125	ENSP00000341805	Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); Belongs to the constitutive coactivator of PPAR-gamma family.	PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...]	0.445
FAM120B	TCTE3	ENSP00000440125	ENSP00000355736	Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); Belongs to the constitutive coactivator of PPAR-gamma family.	Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein light chain Tctex-type family.	0.512
FAM120B	WDR27	ENSP00000440125	ENSP00000416289	Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); Belongs to the constitutive coactivator of PPAR-gamma family.	WD repeat domain 27.	0.526
LRRC23	PACRG	ENSP00000390932	ENSP00000337946	Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	0.528
LRRC23	WDR27	ENSP00000390932	ENSP00000416289	Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.	WD repeat domain 27.	0.530
PACRG	LRRC23	ENSP00000337946	ENSP00000390932	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.	0.528
PACRG	TCTE3	ENSP00000337946	ENSP00000355736	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein light chain Tctex-type family.	0.589