| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFAP69 | SPATA6L | ENSP00000373948 | ENSP00000417063 | Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.473 |
| DMAC1 | SPATA6L | ENSP00000350961 | ENSP00000417063 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.476 |
| DPY19L2 | IQCG | ENSP00000315988 | ENSP00000265239 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation; Belongs to the dpy-19 family. | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. | 0.428 |
| DPY19L2 | SPATA6L | ENSP00000315988 | ENSP00000417063 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation; Belongs to the dpy-19 family. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.403 |
| EFCAB6 | SPATA6L | ENSP00000262726 | ENSP00000417063 | EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.417 |
| IQCG | DPY19L2 | ENSP00000265239 | ENSP00000315988 | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation; Belongs to the dpy-19 family. | 0.428 |
| IQCG | SPATA6L | ENSP00000265239 | ENSP00000417063 | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.506 |
| IQCG | TTLL5 | ENSP00000265239 | ENSP00000298832 | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. Belongs to the tubulin--tyrosine ligase family. | 0.545 |
| KIAA2026 | SPATA6L | ENSP00000382815 | ENSP00000417063 | Uncharacterized protein KIAA2026; KIAA2026. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.426 |
| KIF4A | SPATA6L | ENSP00000363524 | ENSP00000417063 | Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.442 |
| SPATA1 | SPATA6L | ENSP00000492019 | ENSP00000417063 | Spermatogenesis-associated protein 1; Spermatogenesis associated 1. | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | 0.450 |
| SPATA6L | CFAP69 | ENSP00000417063 | ENSP00000373948 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability. | 0.473 |
| SPATA6L | DMAC1 | ENSP00000417063 | ENSP00000350961 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | 0.476 |
| SPATA6L | DPY19L2 | ENSP00000417063 | ENSP00000315988 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation; Belongs to the dpy-19 family. | 0.403 |
| SPATA6L | EFCAB6 | ENSP00000417063 | ENSP00000262726 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. | 0.417 |
| SPATA6L | IQCG | ENSP00000417063 | ENSP00000265239 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. | 0.506 |
| SPATA6L | KIAA2026 | ENSP00000417063 | ENSP00000382815 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Uncharacterized protein KIAA2026; KIAA2026. | 0.426 |
| SPATA6L | KIF4A | ENSP00000417063 | ENSP00000363524 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. | 0.442 |
| SPATA6L | SPATA1 | ENSP00000417063 | ENSP00000492019 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Spermatogenesis-associated protein 1; Spermatogenesis associated 1. | 0.450 |
| SPATA6L | TTLL5 | ENSP00000417063 | ENSP00000298832 | Spermatogenesis associated 6 like; Belongs to the SPATA6 family. | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. Belongs to the tubulin--tyrosine ligase family. | 0.507 |