STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFB121Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family. (76 aa)    
Predicted Functional Partners:
DEFB119
Defensin beta 119.
   
 
 0.855
DEFB129
Beta-defensin 129; Has antibacterial activity.
   
 
 0.821
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.818
DEFB115
Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.812
DEFB108B
Beta-defensin 108B; Has antibacterial activity.
   
 
 0.786
DEFB135
Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.783
DEFB126
Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...]
   
 
 0.773
DEFB131A
Beta-defensin 131A; Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion ; Belongs to the beta-defensin family.
   
 
 0.763
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
 
 0.763
DEFB116
Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.761
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.