node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG1 | COG2 | ENSP00000299886 | ENSP00000355629 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | 0.999 |
COG1 | COG3 | ENSP00000299886 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG1 | COG4 | ENSP00000299886 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG1 | COG7 | ENSP00000299886 | ENSP00000305442 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.999 |
COG1 | COG8 | ENSP00000299886 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG1 | GOLGA5 | ENSP00000299886 | ENSP00000163416 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. | 0.772 |
COG1 | GOLIM4 | ENSP00000299886 | ENSP00000417354 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. | 0.714 |
COG1 | GOLPH3 | ENSP00000299886 | ENSP00000265070 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | 0.634 |
COG1 | GOSR1 | ENSP00000299886 | ENSP00000225724 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.800 |
COG1 | STX5 | ENSP00000299886 | ENSP00000294179 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. | 0.856 |
COG2 | COG1 | ENSP00000355629 | ENSP00000299886 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.999 |
COG2 | COG3 | ENSP00000355629 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG2 | COG4 | ENSP00000355629 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG2 | COG7 | ENSP00000355629 | ENSP00000305442 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.999 |
COG2 | COG8 | ENSP00000355629 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG2 | GOLGA5 | ENSP00000355629 | ENSP00000163416 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. | 0.778 |
COG2 | GOLIM4 | ENSP00000355629 | ENSP00000417354 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. | 0.701 |
COG2 | GOLPH3 | ENSP00000355629 | ENSP00000265070 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | 0.408 |
COG2 | GOSR1 | ENSP00000355629 | ENSP00000225724 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.768 |
COG2 | STX5 | ENSP00000355629 | ENSP00000294179 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. | 0.850 |