node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAT | YIPF6 | ENSP00000241052 | ENSP00000417573 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.777 |
IER3IP1 | YIPF6 | ENSP00000256433 | ENSP00000417573 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.705 |
OPHN1 | STARD8 | ENSP00000347710 | ENSP00000363727 | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. | 0.441 |
OPHN1 | YIPF6 | ENSP00000347710 | ENSP00000417573 | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.757 |
PMM1 | PMM2 | ENSP00000216259 | ENSP00000268261 | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family. | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. | 0.977 |
PMM1 | PUDP | ENSP00000216259 | ENSP00000396452 | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.501 |
PMM1 | YIPF6 | ENSP00000216259 | ENSP00000417573 | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.811 |
PMM2 | PMM1 | ENSP00000268261 | ENSP00000216259 | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family. | 0.977 |
PMM2 | PUDP | ENSP00000268261 | ENSP00000396452 | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.495 |
PMM2 | YIPF6 | ENSP00000268261 | ENSP00000417573 | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.818 |
PUDP | PMM1 | ENSP00000396452 | ENSP00000216259 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Belongs to the eukaryotic PMM family. | 0.501 |
PUDP | PMM2 | ENSP00000396452 | ENSP00000268261 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. | 0.495 |
PUDP | YIPF6 | ENSP00000396452 | ENSP00000417573 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.888 |
STARD8 | OPHN1 | ENSP00000363727 | ENSP00000347710 | StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.441 |
STARD8 | YIPF6 | ENSP00000363727 | ENSP00000417573 | StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.853 |
YIPF1 | YIPF2 | ENSP00000072644 | ENSP00000253031 | Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family. | Protein YIPF2; Yip1 domain family member 2. | 0.632 |
YIPF1 | YIPF6 | ENSP00000072644 | ENSP00000417573 | Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.900 |
YIPF2 | YIPF1 | ENSP00000253031 | ENSP00000072644 | Protein YIPF2; Yip1 domain family member 2. | Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family. | 0.632 |
YIPF2 | YIPF6 | ENSP00000253031 | ENSP00000417573 | Protein YIPF2; Yip1 domain family member 2. | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | 0.870 |
YIPF6 | CAT | ENSP00000417573 | ENSP00000241052 | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. | 0.777 |