STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYLC2Cylicin-2; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. (348 aa)    
Predicted Functional Partners:
CCIN
Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation.
   
  
 0.989
CYLC1
Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
   
 
0.663
CSNKA2IP
Casein kinase II subunit alpha'-interacting protein; May play a role in chromatin regulation of male germ cells.
   
  
 0.574
CATSPERG
Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
      
 0.564
SPATA31E1
Spermatogenesis-associated protein 31E1; May play a role in spermatogenesis; Belongs to the SPATA31 family.
   
  
 0.553
CBY2
Chibby family member 2.
   
  
 0.522
EFCAB1
EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1.
   
 
 0.521
SPATA6
Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits; Belongs to the SPATA6 family.
   
 
 0.517
OR2T10
Olfactory receptor 2T10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.505
ZCCHC2
Zinc finger CCHC-type containing 2.
    
 
 0.465
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.