node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AZI2 | CMC1 | ENSP00000419371 | ENSP00000418348 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 0.512 |
CHCHD7 | CMC1 | ENSP00000306425 | ENSP00000418348 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 0.503 |
CHCHD7 | CMC2 | ENSP00000306425 | ENSP00000219400 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | 0.744 |
CHCHD7 | COA5 | ENSP00000306425 | ENSP00000330730 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.786 |
CHCHD7 | COA6 | ENSP00000306425 | ENSP00000355574 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.742 |
CHCHD7 | COX14 | ENSP00000306425 | ENSP00000326052 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | 0.441 |
CHCHD7 | COX17 | ENSP00000306425 | ENSP00000261070 | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.860 |
CMC1 | AZI2 | ENSP00000418348 | ENSP00000419371 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | 0.512 |
CMC1 | CHCHD7 | ENSP00000418348 | ENSP00000306425 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | 0.503 |
CMC1 | CMC2 | ENSP00000418348 | ENSP00000219400 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | 0.512 |
CMC1 | COA3 | ENSP00000418348 | ENSP00000354762 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly; Belongs to the COA3 family. | 0.856 |
CMC1 | COA5 | ENSP00000418348 | ENSP00000330730 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.632 |
CMC1 | COA6 | ENSP00000418348 | ENSP00000355574 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] | 0.528 |
CMC1 | COX14 | ENSP00000418348 | ENSP00000326052 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. | 0.680 |
CMC1 | COX16 | ENSP00000418348 | ENSP00000374562 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT- CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT- CO2/COX2 a [...] | 0.573 |
CMC1 | COX17 | ENSP00000418348 | ENSP00000261070 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). | 0.620 |
CMC1 | TIMM10 | ENSP00000418348 | ENSP00000257245 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Belongs to the small Tim family. | 0.514 |
CMC2 | CHCHD7 | ENSP00000219400 | ENSP00000306425 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family. | 0.744 |
CMC2 | CMC1 | ENSP00000219400 | ENSP00000418348 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 0.512 |
CMC2 | COA5 | ENSP00000219400 | ENSP00000330730 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family. | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process. | 0.468 |