node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM110A | SNX29 | ENSP00000354163 | ENSP00000456480 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | Sorting nexin 29. | 0.419 |
FAM110A | TAFA1 | ENSP00000354163 | ENSP00000418575 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.436 |
FAM163A | TAFA1 | ENSP00000354891 | ENSP00000418575 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.414 |
GPR1 | TAFA1 | ENSP00000480405 | ENSP00000418575 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.657 |
NECAB2 | TAFA1 | ENSP00000307449 | ENSP00000418575 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.544 |
NRXN1 | NRXN2 | ENSP00000385142 | ENSP00000265459 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. | 0.922 |
NRXN1 | NXPH1 | ENSP00000385142 | ENSP00000384551 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | 0.973 |
NRXN1 | TAFA1 | ENSP00000385142 | ENSP00000418575 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.525 |
NRXN2 | NRXN1 | ENSP00000265459 | ENSP00000385142 | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.922 |
NRXN2 | NXPH1 | ENSP00000265459 | ENSP00000384551 | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | 0.827 |
NRXN2 | TAFA1 | ENSP00000265459 | ENSP00000418575 | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.537 |
NXPH1 | NRXN1 | ENSP00000384551 | ENSP00000385142 | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.973 |
NXPH1 | NRXN2 | ENSP00000384551 | ENSP00000265459 | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. | 0.827 |
NXPH1 | TAFA1 | ENSP00000384551 | ENSP00000418575 | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.428 |
SNX29 | FAM110A | ENSP00000456480 | ENSP00000354163 | Sorting nexin 29. | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | 0.419 |
SNX29 | TAFA1 | ENSP00000456480 | ENSP00000418575 | Sorting nexin 29. | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | 0.412 |
TAFA1 | FAM110A | ENSP00000418575 | ENSP00000354163 | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | 0.436 |
TAFA1 | FAM163A | ENSP00000418575 | ENSP00000354891 | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.414 |
TAFA1 | GPR1 | ENSP00000418575 | ENSP00000480405 | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.657 |
TAFA1 | NECAB2 | ENSP00000418575 | ENSP00000307449 | Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family. | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | 0.544 |