node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTBD9 | FAF1 | ENSP00000418751 | ENSP00000379457 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | FAS-associated factor 1; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity). | 0.994 |
BTBD9 | MAP2K5 | ENSP00000418751 | ENSP00000178640 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | 0.785 |
BTBD9 | MRPL19 | ENSP00000418751 | ENSP00000377486 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Mitochondrial ribosomal protein L19. | 0.781 |
BTBD9 | MRPL23 | ENSP00000418751 | ENSP00000380466 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Mitochondrial ribosomal protein L23. | 0.787 |
BTBD9 | MRPL27 | ENSP00000418751 | ENSP00000225969 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Mitochondrial ribosomal protein L27. | 0.789 |
BTBD9 | MRPL3 | ENSP00000418751 | ENSP00000264995 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Mitochondrial ribosomal protein L3. | 0.828 |
BTBD9 | MRPL46 | ENSP00000418751 | ENSP00000312311 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.789 |
BTBD9 | SKOR1 | ENSP00000418751 | ENSP00000343200 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | SKI family transcriptional corepressor 1. | 0.884 |
BTBD9 | UBXN1 | ENSP00000418751 | ENSP00000294119 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | 0.994 |
BTBD9 | UBXN7 | ENSP00000418751 | ENSP00000296328 | BTB/POZ domain-containing protein 9; BTB domain containing 9. | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. | 0.994 |
FAF1 | BTBD9 | ENSP00000379457 | ENSP00000418751 | FAS-associated factor 1; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity). | BTB/POZ domain-containing protein 9; BTB domain containing 9. | 0.994 |
FAF1 | UBXN1 | ENSP00000379457 | ENSP00000294119 | FAS-associated factor 1; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity). | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | 0.999 |
FAF1 | UBXN7 | ENSP00000379457 | ENSP00000296328 | FAS-associated factor 1; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity). | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. | 0.999 |
MAP2K5 | BTBD9 | ENSP00000178640 | ENSP00000418751 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | BTB/POZ domain-containing protein 9; BTB domain containing 9. | 0.785 |
MAP2K5 | SKOR1 | ENSP00000178640 | ENSP00000343200 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | SKI family transcriptional corepressor 1. | 0.974 |
MRPL19 | BTBD9 | ENSP00000377486 | ENSP00000418751 | Mitochondrial ribosomal protein L19. | BTB/POZ domain-containing protein 9; BTB domain containing 9. | 0.781 |
MRPL19 | MRPL23 | ENSP00000377486 | ENSP00000380466 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L23. | 0.998 |
MRPL19 | MRPL27 | ENSP00000377486 | ENSP00000225969 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L27. | 0.999 |
MRPL19 | MRPL3 | ENSP00000377486 | ENSP00000264995 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L3. | 0.999 |
MRPL19 | MRPL46 | ENSP00000377486 | ENSP00000312311 | Mitochondrial ribosomal protein L19. | Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.995 |