node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFAP126 | RIIAD1 | ENSP00000356951 | ENSP00000419249 | Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.432 |
EFCAB10 | RIIAD1 | ENSP00000417841 | ENSP00000419249 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.447 |
EFCAB10 | TEX55 | ENSP00000417841 | ENSP00000295622 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10. | Testis expressed 55. | 0.639 |
FAM89B | RIIAD1 | ENSP00000431459 | ENSP00000419249 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.561 |
FAM89B | SLC66A2 | ENSP00000431459 | ENSP00000380880 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Solute carrier family 66 member 2. | 0.595 |
RIIAD1 | CFAP126 | ENSP00000419249 | ENSP00000356951 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. | 0.432 |
RIIAD1 | EFCAB10 | ENSP00000419249 | ENSP00000417841 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10. | 0.447 |
RIIAD1 | FAM89B | ENSP00000419249 | ENSP00000431459 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | 0.561 |
RIIAD1 | SLC66A2 | ENSP00000419249 | ENSP00000380880 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Solute carrier family 66 member 2. | 0.465 |
RIIAD1 | SMIM5 | ENSP00000419249 | ENSP00000477017 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Small integral membrane protein 5. | 0.422 |
RIIAD1 | TCTA | ENSP00000419249 | ENSP00000273590 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.429 |
RIIAD1 | TEX55 | ENSP00000419249 | ENSP00000295622 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Testis expressed 55. | 0.528 |
RIIAD1 | TRAF3IP1 | ENSP00000419249 | ENSP00000362424 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | 0.594 |
SLC66A2 | FAM89B | ENSP00000380880 | ENSP00000431459 | Solute carrier family 66 member 2. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | 0.595 |
SLC66A2 | RIIAD1 | ENSP00000380880 | ENSP00000419249 | Solute carrier family 66 member 2. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.465 |
SMIM5 | RIIAD1 | ENSP00000477017 | ENSP00000419249 | Small integral membrane protein 5. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.422 |
TCTA | RIIAD1 | ENSP00000273590 | ENSP00000419249 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.429 |
TEX55 | EFCAB10 | ENSP00000295622 | ENSP00000417841 | Testis expressed 55. | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10. | 0.639 |
TEX55 | RIIAD1 | ENSP00000295622 | ENSP00000419249 | Testis expressed 55. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.528 |
TRAF3IP1 | RIIAD1 | ENSP00000362424 | ENSP00000419249 | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.594 |