node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf52 | CCDC84 | ENSP00000419417 | ENSP00000334767 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Coiled-coil domain-containing protein 84. | 0.406 |
C1orf52 | DEF6 | ENSP00000419417 | ENSP00000319831 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Differentially expressed in FDCP 6 homolog; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). | 0.434 |
C1orf52 | DENND2D | ENSP00000419417 | ENSP00000350266 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | DENN domain-containing protein 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. | 0.439 |
C1orf52 | ISL2 | ENSP00000419417 | ENSP00000290759 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | 0.405 |
C1orf52 | LHX4 | ENSP00000419417 | ENSP00000263726 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA. | 0.447 |
C1orf52 | RBM33 | ENSP00000419417 | ENSP00000384160 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | RNA binding motif protein 33. | 0.450 |
C1orf52 | SYDE2 | ENSP00000419417 | ENSP00000340594 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.477 |
C1orf52 | UTP25 | ENSP00000419417 | ENSP00000419005 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs. | 0.418 |
C1orf52 | ZNHIT6 | ENSP00000419417 | ENSP00000359606 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family. | 0.466 |
CCDC84 | C1orf52 | ENSP00000334767 | ENSP00000419417 | Coiled-coil domain-containing protein 84. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.406 |
DEF6 | C1orf52 | ENSP00000319831 | ENSP00000419417 | Differentially expressed in FDCP 6 homolog; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.434 |
DENND2D | C1orf52 | ENSP00000350266 | ENSP00000419417 | DENN domain-containing protein 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.439 |
ISL2 | C1orf52 | ENSP00000290759 | ENSP00000419417 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.405 |
ISL2 | LHX4 | ENSP00000290759 | ENSP00000263726 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA. | 0.967 |
LHX4 | C1orf52 | ENSP00000263726 | ENSP00000419417 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.447 |
LHX4 | ISL2 | ENSP00000263726 | ENSP00000290759 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA. | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. | 0.967 |
RBM33 | C1orf52 | ENSP00000384160 | ENSP00000419417 | RNA binding motif protein 33. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.450 |
SYDE2 | C1orf52 | ENSP00000340594 | ENSP00000419417 | Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.477 |
UTP25 | C1orf52 | ENSP00000419005 | ENSP00000419417 | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.418 |
ZNHIT6 | C1orf52 | ENSP00000359606 | ENSP00000419417 | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family. | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family. | 0.466 |