node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTF3 | BTF3L4 | ENSP00000369965 | ENSP00000360664 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | 0.747 |
BTF3 | EEF1G | ENSP00000369965 | ENSP00000331901 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. | 0.772 |
BTF3 | NACAD | ENSP00000369965 | ENSP00000420477 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity); Belongs to the NAC-alpha family. | 0.919 |
BTF3 | RPL13 | ENSP00000369965 | ENSP00000307889 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Ribosomal protein L13. | 0.945 |
BTF3 | RPL18 | ENSP00000369965 | ENSP00000447001 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | 60S ribosomal protein L18; Component of the large ribosomal subunit. | 0.981 |
BTF3 | RPL18A | ENSP00000369965 | ENSP00000222247 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. | 0.982 |
BTF3 | RPL5 | ENSP00000369965 | ENSP00000359345 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.954 |
BTF3 | RPL7A | ENSP00000369965 | ENSP00000361076 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Ribosomal protein L7a. | 0.975 |
BTF3 | RPS3A | ENSP00000369965 | ENSP00000346050 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. | 0.912 |
BTF3 | RPS8 | ENSP00000369965 | ENSP00000379888 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. | 0.900 |
BTF3L4 | BTF3 | ENSP00000360664 | ENSP00000369965 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. | 0.747 |
BTF3L4 | EEF1G | ENSP00000360664 | ENSP00000331901 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. | 0.646 |
BTF3L4 | NACAD | ENSP00000360664 | ENSP00000420477 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity); Belongs to the NAC-alpha family. | 0.879 |
BTF3L4 | RPL13 | ENSP00000360664 | ENSP00000307889 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Ribosomal protein L13. | 0.572 |
BTF3L4 | RPL18 | ENSP00000360664 | ENSP00000447001 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | 60S ribosomal protein L18; Component of the large ribosomal subunit. | 0.513 |
BTF3L4 | RPL18A | ENSP00000360664 | ENSP00000222247 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. | 0.464 |
BTF3L4 | RPL5 | ENSP00000360664 | ENSP00000359345 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.433 |
BTF3L4 | RPL7A | ENSP00000360664 | ENSP00000361076 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Ribosomal protein L7a. | 0.509 |
BTF3L4 | RPS3A | ENSP00000360664 | ENSP00000346050 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family. | 0.663 |
BTF3L4 | RPS8 | ENSP00000360664 | ENSP00000379888 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family. | Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. | 0.735 |