PRB1 protein (human) - STRING interaction network

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gene neighborhood

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Score

PRB1

Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1. (198 aa)

Predicted Functional Partners:

PRB4

0.999

PRB2

0.909

PRH2

0.890

C4BPA

0.818

PRB3

0.817

RB1

0.786

STATH

0.673

GTF2B

0.666

SMR3B

0.626

PRR4

0.623

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4BPA	PRB1	ENSP00000356037	ENSP00000420826	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	0.818
C4BPA	PRB2	ENSP00000356037	ENSP00000374013	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	0.728
C4BPA	PRB3	ENSP00000356037	ENSP00000442626	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.	0.744
C4BPA	PRB4	ENSP00000356037	ENSP00000279575	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.	0.750
C4BPA	PRH2	ENSP00000356037	ENSP00000379682	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.	0.769
C4BPA	STATH	ENSP00000356037	ENSP00000246895	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.774
GTF2B	PRB1	ENSP00000359531	ENSP00000420826	Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter- [...]	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	0.666
PRB1	C4BPA	ENSP00000420826	ENSP00000356037	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	0.818
PRB1	GTF2B	ENSP00000420826	ENSP00000359531	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter- [...]	0.666
PRB1	PRB2	ENSP00000420826	ENSP00000374013	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	0.909
PRB1	PRB3	ENSP00000420826	ENSP00000442626	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.	0.817
PRB1	PRB4	ENSP00000420826	ENSP00000279575	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.	0.999
PRB1	PRH2	ENSP00000420826	ENSP00000379682	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.	0.890
PRB1	PRR4	ENSP00000420826	ENSP00000228811	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Proline-rich protein 4; Proline rich 4.	0.623
PRB1	RB1	ENSP00000420826	ENSP00000267163	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]	0.786
PRB1	SMR3B	ENSP00000420826	ENSP00000481313	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family.	0.626
PRB1	STATH	ENSP00000420826	ENSP00000246895	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.673
PRB2	C4BPA	ENSP00000374013	ENSP00000356037	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	0.728
PRB2	PRB1	ENSP00000374013	ENSP00000420826	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	0.909
PRB2	PRH2	ENSP00000374013	ENSP00000379682	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.	0.864