TIGD5 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

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file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DPPA4	TIGD5	ENSP00000335306	ENSP00000421489	Developmental pluripotency-associated protein 4; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.	Tigger transposable element derived 5.	0.567
HARBI1	POGK	ENSP00000317743	ENSP00000356849	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Pogo transposable element derived with KRAB domain.	0.579
HARBI1	TIGD4	ENSP00000317743	ENSP00000355162	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Tigger transposable element derived 4.	0.532
HARBI1	TIGD5	ENSP00000317743	ENSP00000421489	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Tigger transposable element derived 5.	0.550
MAGEA4	TIGD5	ENSP00000353379	ENSP00000421489	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	Tigger transposable element derived 5.	0.820
MROH6	TIGD5	ENSP00000381857	ENSP00000421489	Maestro heat like repeat family member 6.	Tigger transposable element derived 5.	0.639
P4HA3	TIGD5	ENSP00000401749	ENSP00000421489	Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.	Tigger transposable element derived 5.	0.580
POGK	HARBI1	ENSP00000356849	ENSP00000317743	Pogo transposable element derived with KRAB domain.	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	0.579
POGK	TIGD5	ENSP00000356849	ENSP00000421489	Pogo transposable element derived with KRAB domain.	Tigger transposable element derived 5.	0.616
RMND5A	TIGD5	ENSP00000283632	ENSP00000421489	E3 ubiquitin-protein transferase RMND5A; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.	Tigger transposable element derived 5.	0.638
TIGD4	HARBI1	ENSP00000355162	ENSP00000317743	Tigger transposable element derived 4.	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	0.532
TIGD4	TIGD5	ENSP00000355162	ENSP00000421489	Tigger transposable element derived 4.	Tigger transposable element derived 5.	0.546
TIGD5	DPPA4	ENSP00000421489	ENSP00000335306	Tigger transposable element derived 5.	Developmental pluripotency-associated protein 4; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.	0.567
TIGD5	HARBI1	ENSP00000421489	ENSP00000317743	Tigger transposable element derived 5.	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	0.550
TIGD5	MAGEA4	ENSP00000421489	ENSP00000353379	Tigger transposable element derived 5.	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	0.820
TIGD5	MROH6	ENSP00000421489	ENSP00000381857	Tigger transposable element derived 5.	Maestro heat like repeat family member 6.	0.639
TIGD5	P4HA3	ENSP00000421489	ENSP00000401749	Tigger transposable element derived 5.	Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.	0.580
TIGD5	POGK	ENSP00000421489	ENSP00000356849	Tigger transposable element derived 5.	Pogo transposable element derived with KRAB domain.	0.616
TIGD5	RMND5A	ENSP00000421489	ENSP00000283632	Tigger transposable element derived 5.	E3 ubiquitin-protein transferase RMND5A; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.	0.638
TIGD5	TIGD4	ENSP00000421489	ENSP00000355162	Tigger transposable element derived 5.	Tigger transposable element derived 4.	0.546