HMGXB3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1	HMGXB3	ENSP00000477213	ENSP00000421917	Amyloid-beta A4 precursor protein-binding family B member 1; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 [...]	HMG-box containing 3.	0.456
HMGXB3	APBB1	ENSP00000421917	ENSP00000477213	HMG-box containing 3.	Amyloid-beta A4 precursor protein-binding family B member 1; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 [...]	0.456
HMGXB3	MEX3A	ENSP00000421917	ENSP00000432845	HMG-box containing 3.	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	0.457
HMGXB3	NADK2	ENSP00000421917	ENSP00000371362	HMG-box containing 3.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	0.439
HMGXB3	NRSN2	ENSP00000421917	ENSP00000371728	HMG-box containing 3.	Neurensin-2; May play a role in maintenance and/or transport of vesicles; Belongs to the VMP family.	0.477
HMGXB3	SLC26A2	ENSP00000421917	ENSP00000286298	HMG-box containing 3.	Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation.	0.631
HMGXB3	SNRPE	ENSP00000421917	ENSP00000400591	HMG-box containing 3.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.422
HMGXB3	TIGD6	ENSP00000421917	ENSP00000296736	HMG-box containing 3.	Tigger transposable element derived 6.	0.491
MEX3A	HMGXB3	ENSP00000432845	ENSP00000421917	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	HMG-box containing 3.	0.457
MEX3A	SNRPE	ENSP00000432845	ENSP00000400591	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	0.481
NADK2	HMGXB3	ENSP00000371362	ENSP00000421917	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	HMG-box containing 3.	0.439
NRSN2	HMGXB3	ENSP00000371728	ENSP00000421917	Neurensin-2; May play a role in maintenance and/or transport of vesicles; Belongs to the VMP family.	HMG-box containing 3.	0.477
SLC26A2	HMGXB3	ENSP00000286298	ENSP00000421917	Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation.	HMG-box containing 3.	0.631
SNRPE	HMGXB3	ENSP00000400591	ENSP00000421917	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	HMG-box containing 3.	0.422
SNRPE	MEX3A	ENSP00000400591	ENSP00000432845	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	0.481
TIGD6	HMGXB3	ENSP00000296736	ENSP00000421917	Tigger transposable element derived 6.	HMG-box containing 3.	0.491