NFXL1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2C2	CMIP	ENSP00000397925	ENSP00000446100	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	0.929
ATP2C2	DNAAF4	ENSP00000397925	ENSP00000323275	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	0.734
ATP2C2	NFXL1	ENSP00000397925	ENSP00000422037	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.657
CMIP	ATP2C2	ENSP00000446100	ENSP00000397925	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.929
CMIP	DNAAF4	ENSP00000446100	ENSP00000323275	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	0.575
CMIP	NFXL1	ENSP00000446100	ENSP00000422037	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.610
COL20A1	NFXL1	ENSP00000351767	ENSP00000422037	Collagen alpha-1(XX) chain; Probable collagen protein.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.904
DNAAF4	ATP2C2	ENSP00000323275	ENSP00000397925	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.734
DNAAF4	CMIP	ENSP00000323275	ENSP00000446100	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	0.575
DNAAF4	NFXL1	ENSP00000323275	ENSP00000422037	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.569
EDC3	NFXL1	ENSP00000497737	ENSP00000422037	Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.587
EDC3	RINT1	ENSP00000497737	ENSP00000257700	Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.	RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control ; Belongs to the RINT1 family.	0.677
H4C6	NFXL1	ENSP00000244537	ENSP00000422037	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	0.544
NFXL1	ATP2C2	ENSP00000422037	ENSP00000397925	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.657
NFXL1	CMIP	ENSP00000422037	ENSP00000446100	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	0.610
NFXL1	COL20A1	ENSP00000422037	ENSP00000351767	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	Collagen alpha-1(XX) chain; Probable collagen protein.	0.904
NFXL1	DNAAF4	ENSP00000422037	ENSP00000323275	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	0.569
NFXL1	EDC3	ENSP00000422037	ENSP00000497737	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.	0.587
NFXL1	H4C6	ENSP00000422037	ENSP00000244537	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.544
NFXL1	RINT1	ENSP00000422037	ENSP00000257700	NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.	RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control ; Belongs to the RINT1 family.	0.587