node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | TRIML2 | ENSP00000263182 | ENSP00000422581 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.475 |
FRG1 | TRIML2 | ENSP00000226798 | ENSP00000422581 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.512 |
NECAB2 | TRIML2 | ENSP00000307449 | ENSP00000422581 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.504 |
PHTF1 | SWT1 | ENSP00000358617 | ENSP00000356470 | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | Transcriptional protein SWT1; SWT1 RNA endoribonuclease homolog. | 0.509 |
PHTF1 | TRIML2 | ENSP00000358617 | ENSP00000422581 | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.476 |
SRGAP2 | TRIML2 | ENSP00000459615 | ENSP00000422581 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.476 |
SUMO2 | TRIML2 | ENSP00000405965 | ENSP00000422581 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polyme [...] | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.447 |
SUMO2 | ZBTB33 | ENSP00000405965 | ENSP00000450969 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polyme [...] | Transcriptional regulator Kaiso; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the re [...] | 0.655 |
SWT1 | PHTF1 | ENSP00000356470 | ENSP00000358617 | Transcriptional protein SWT1; SWT1 RNA endoribonuclease homolog. | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | 0.509 |
SWT1 | TRIML2 | ENSP00000356470 | ENSP00000422581 | Transcriptional protein SWT1; SWT1 RNA endoribonuclease homolog. | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | 0.475 |
TRIML2 | BBOX1 | ENSP00000422581 | ENSP00000263182 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.475 |
TRIML2 | FRG1 | ENSP00000422581 | ENSP00000226798 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family. | 0.512 |
TRIML2 | NECAB2 | ENSP00000422581 | ENSP00000307449 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. | 0.504 |
TRIML2 | PHTF1 | ENSP00000422581 | ENSP00000358617 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | 0.476 |
TRIML2 | SRGAP2 | ENSP00000422581 | ENSP00000459615 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.476 |
TRIML2 | SUMO2 | ENSP00000422581 | ENSP00000405965 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polyme [...] | 0.447 |
TRIML2 | SWT1 | ENSP00000422581 | ENSP00000356470 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Transcriptional protein SWT1; SWT1 RNA endoribonuclease homolog. | 0.475 |
TRIML2 | TTC16 | ENSP00000422581 | ENSP00000362386 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Tetratricopeptide repeat domain 16. | 0.596 |
TRIML2 | ZBTB33 | ENSP00000422581 | ENSP00000450969 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Transcriptional regulator Kaiso; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the re [...] | 0.483 |
TRIML2 | ZFP42 | ENSP00000422581 | ENSP00000317686 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2. | Zinc finger protein 42 homolog; Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). | 0.611 |