node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMMD8 | DCUN1D4 | ENSP00000370984 | ENSP00000389900 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4. | 0.615 |
COMMD8 | OCIAD2 | ENSP00000370984 | ENSP00000423014 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | OCIA domain containing 2. | 0.479 |
COMMD8 | RNF150 | ENSP00000370984 | ENSP00000425840 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Ring finger protein 150. | 0.485 |
COMMD8 | SMIM14 | ENSP00000370984 | ENSP00000295958 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Small integral membrane protein 14. | 0.510 |
COMMD8 | SYNPO2 | ENSP00000370984 | ENSP00000306015 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Synaptopodin-2; Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane- tethering [...] | 0.427 |
COMMD8 | TIGD4 | ENSP00000370984 | ENSP00000355162 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Tigger transposable element derived 4. | 0.539 |
COMMD8 | TMEM131L | ENSP00000370984 | ENSP00000386787 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. | 0.525 |
DCUN1D4 | COMMD8 | ENSP00000389900 | ENSP00000370984 | DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4. | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | 0.615 |
DCUN1D4 | OCIAD2 | ENSP00000389900 | ENSP00000423014 | DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4. | OCIA domain containing 2. | 0.507 |
NRIP3 | OCIAD2 | ENSP00000310205 | ENSP00000423014 | Nuclear receptor interacting protein 3. | OCIA domain containing 2. | 0.460 |
NRIP3 | RNF182 | ENSP00000310205 | ENSP00000420465 | Nuclear receptor interacting protein 3. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.414 |
NRIP3 | TBC1D30 | ENSP00000310205 | ENSP00000440207 | Nuclear receptor interacting protein 3. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. | 0.559 |
OCIAD2 | COMMD8 | ENSP00000423014 | ENSP00000370984 | OCIA domain containing 2. | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. | 0.479 |
OCIAD2 | DCUN1D4 | ENSP00000423014 | ENSP00000389900 | OCIA domain containing 2. | DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4. | 0.507 |
OCIAD2 | NRIP3 | ENSP00000423014 | ENSP00000310205 | OCIA domain containing 2. | Nuclear receptor interacting protein 3. | 0.460 |
OCIAD2 | RNF150 | ENSP00000423014 | ENSP00000425840 | OCIA domain containing 2. | Ring finger protein 150. | 0.462 |
OCIAD2 | RNF182 | ENSP00000423014 | ENSP00000420465 | OCIA domain containing 2. | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. | 0.469 |
OCIAD2 | SMIM14 | ENSP00000423014 | ENSP00000295958 | OCIA domain containing 2. | Small integral membrane protein 14. | 0.495 |
OCIAD2 | SYNPO2 | ENSP00000423014 | ENSP00000306015 | OCIA domain containing 2. | Synaptopodin-2; Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane- tethering [...] | 0.472 |
OCIAD2 | TBC1D30 | ENSP00000423014 | ENSP00000440207 | OCIA domain containing 2. | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. | 0.470 |