TMEM167A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPZ1	SCFD1	ENSP00000449270	ENSP00000390783	Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...]	Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).	0.552
COPZ1	TMEM167A	ENSP00000449270	ENSP00000424707	Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...]	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.491
DPM2	TMEM167A	ENSP00000322181	ENSP00000424707	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.500
FAM162B	TMEM167A	ENSP00000357545	ENSP00000424707	Protein FAM162B; Family with sequence similarity 162 member B.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.510
IER3IP1	TMEM167A	ENSP00000256433	ENSP00000424707	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.763
RBM41	SF3B5	ENSP00000361557	ENSP00000356541	RNA-binding protein 41; May bind RNA.	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	0.944
RBM41	TMEM167A	ENSP00000361557	ENSP00000424707	RNA-binding protein 41; May bind RNA.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.532
RBM41	UTP11	ENSP00000361557	ENSP00000362105	RNA-binding protein 41; May bind RNA.	Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.499
SCFD1	COPZ1	ENSP00000390783	ENSP00000449270	Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).	Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...]	0.552
SCFD1	TMEM167A	ENSP00000390783	ENSP00000424707	Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.491
SF3B5	RBM41	ENSP00000356541	ENSP00000361557	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	RNA-binding protein 41; May bind RNA.	0.944
SF3B5	TMEM167A	ENSP00000356541	ENSP00000424707	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.575
SRP9	TMEM167A	ENSP00000305230	ENSP00000424707	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	0.507
TMEM167A	COPZ1	ENSP00000424707	ENSP00000449270	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...]	0.491
TMEM167A	DPM2	ENSP00000424707	ENSP00000322181	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.	0.500
TMEM167A	FAM162B	ENSP00000424707	ENSP00000357545	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Protein FAM162B; Family with sequence similarity 162 member B.	0.510
TMEM167A	IER3IP1	ENSP00000424707	ENSP00000256433	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity); Belongs to the YOS1 family.	0.763
TMEM167A	RBM41	ENSP00000424707	ENSP00000361557	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	RNA-binding protein 41; May bind RNA.	0.532
TMEM167A	SCFD1	ENSP00000424707	ENSP00000390783	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).	0.491
TMEM167A	SF3B5	ENSP00000424707	ENSP00000356541	Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.	Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.	0.575