node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LUC7L3 | PNISR | ENSP00000376919 | ENSP00000496842 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.999 |
LUC7L3 | PRPF39 | ENSP00000376919 | ENSP00000348010 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.921 |
LUC7L3 | PRPF40A | ENSP00000376919 | ENSP00000386458 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.897 |
LUC7L3 | RBM25 | ENSP00000376919 | ENSP00000261973 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.989 |
LUC7L3 | RBM39 | ENSP00000376919 | ENSP00000253363 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.957 |
LUC7L3 | SART1 | ENSP00000376919 | ENSP00000310448 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family. | 0.904 |
LUC7L3 | SNRNP70 | ENSP00000376919 | ENSP00000472998 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.947 |
LUC7L3 | SNRPD2 | ENSP00000376919 | ENSP00000342374 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.896 |
LUC7L3 | SNRPF | ENSP00000376919 | ENSP00000266735 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.896 |
LUC7L3 | SRSF11 | ENSP00000376919 | ENSP00000359988 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | 0.915 |
PNISR | LUC7L3 | ENSP00000496842 | ENSP00000376919 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.999 |
PNISR | PRPF39 | ENSP00000496842 | ENSP00000348010 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.849 |
PNISR | RBM25 | ENSP00000496842 | ENSP00000261973 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.713 |
PNISR | RBM39 | ENSP00000496842 | ENSP00000253363 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.805 |
PNISR | SNRNP70 | ENSP00000496842 | ENSP00000472998 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.756 |
PNISR | SRSF11 | ENSP00000496842 | ENSP00000359988 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | 0.945 |
PRPF39 | LUC7L3 | ENSP00000348010 | ENSP00000376919 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.921 |
PRPF39 | PNISR | ENSP00000348010 | ENSP00000496842 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.849 |
PRPF39 | PRPF40A | ENSP00000348010 | ENSP00000386458 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.676 |
PRPF39 | RBM25 | ENSP00000348010 | ENSP00000261973 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.942 |