node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACRBP | ADAM2 | ENSP00000229243 | ENSP00000265708 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. | 0.617 |
ACRBP | CAGE1 | ENSP00000229243 | ENSP00000425493 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | Cancer-associated gene 1 protein; Cancer antigen 1. | 0.606 |
ACRBP | DKKL1 | ENSP00000229243 | ENSP00000221498 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.412 |
ACRBP | MAGEC1 | ENSP00000229243 | ENSP00000285879 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | Melanoma-associated antigen C1; MAGE family member C1. | 0.540 |
ACRBP | RAB11B | ENSP00000229243 | ENSP00000333547 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regul [...] | 0.477 |
ADAM2 | ACRBP | ENSP00000265708 | ENSP00000229243 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | 0.617 |
ADAM2 | CAGE1 | ENSP00000265708 | ENSP00000425493 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. | Cancer-associated gene 1 protein; Cancer antigen 1. | 0.670 |
ADAM2 | MAGEC1 | ENSP00000265708 | ENSP00000285879 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. | Melanoma-associated antigen C1; MAGE family member C1. | 0.523 |
CAGE1 | ACRBP | ENSP00000425493 | ENSP00000229243 | Cancer-associated gene 1 protein; Cancer antigen 1. | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. | 0.606 |
CAGE1 | ADAM2 | ENSP00000425493 | ENSP00000265708 | Cancer-associated gene 1 protein; Cancer antigen 1. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. | 0.670 |
CAGE1 | CNDP2 | ENSP00000425493 | ENSP00000325548 | Cancer-associated gene 1 protein; Cancer antigen 1. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | 0.791 |
CAGE1 | CTAG1B | ENSP00000425493 | ENSP00000332602 | Cancer-associated gene 1 protein; Cancer antigen 1. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.840 |
CAGE1 | CTXN1 | ENSP00000425493 | ENSP00000313226 | Cancer-associated gene 1 protein; Cancer antigen 1. | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | 0.620 |
CAGE1 | DKKL1 | ENSP00000425493 | ENSP00000221498 | Cancer-associated gene 1 protein; Cancer antigen 1. | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.761 |
CAGE1 | KLK3 | ENSP00000425493 | ENSP00000314151 | Cancer-associated gene 1 protein; Cancer antigen 1. | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. | 0.604 |
CAGE1 | MAGEC1 | ENSP00000425493 | ENSP00000285879 | Cancer-associated gene 1 protein; Cancer antigen 1. | Melanoma-associated antigen C1; MAGE family member C1. | 0.608 |
CAGE1 | RAB11B | ENSP00000425493 | ENSP00000333547 | Cancer-associated gene 1 protein; Cancer antigen 1. | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regul [...] | 0.793 |
CAGE1 | RAB1A | ENSP00000425493 | ENSP00000387286 | Cancer-associated gene 1 protein; Cancer antigen 1. | Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] | 0.579 |
CNDP2 | CAGE1 | ENSP00000325548 | ENSP00000425493 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Cancer-associated gene 1 protein; Cancer antigen 1. | 0.791 |
CNDP2 | DKKL1 | ENSP00000325548 | ENSP00000221498 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N-lactoyl-amino acids from lactate [...] | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.583 |