TMEM267 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX39A	TMEM267	ENSP00000242776	ENSP00000426067	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	Transmembrane protein 267.	0.468
HDHD2	TMEM267	ENSP00000300605	ENSP00000426067	Haloacid dehalogenase like hydrolase domain containing 2.	Transmembrane protein 267.	0.491
HDHD2	WDR70	ENSP00000300605	ENSP00000265107	Haloacid dehalogenase like hydrolase domain containing 2.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.480
LMBRD2	TMEM267	ENSP00000296603	ENSP00000426067	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	Transmembrane protein 267.	0.408
NADK2	TMEM267	ENSP00000371362	ENSP00000426067	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	Transmembrane protein 267.	0.414
NADK2	WDR70	ENSP00000371362	ENSP00000265107	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.475
PAIP1	TMEM267	ENSP00000302768	ENSP00000426067	Polyadenylate-binding protein-interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant o [...]	Transmembrane protein 267.	0.528
PRXL2C	TMEM267	ENSP00000364382	ENSP00000426067	Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.	Transmembrane protein 267.	0.465
TMEM267	DDX39A	ENSP00000426067	ENSP00000242776	Transmembrane protein 267.	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	0.468
TMEM267	HDHD2	ENSP00000426067	ENSP00000300605	Transmembrane protein 267.	Haloacid dehalogenase like hydrolase domain containing 2.	0.491
TMEM267	LMBRD2	ENSP00000426067	ENSP00000296603	Transmembrane protein 267.	G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable); Belongs to the LIMR family.	0.408
TMEM267	NADK2	ENSP00000426067	ENSP00000371362	Transmembrane protein 267.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	0.414
TMEM267	PAIP1	ENSP00000426067	ENSP00000302768	Transmembrane protein 267.	Polyadenylate-binding protein-interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant o [...]	0.528
TMEM267	PRXL2C	ENSP00000426067	ENSP00000364382	Transmembrane protein 267.	Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.	0.465
TMEM267	WDR70	ENSP00000426067	ENSP00000265107	Transmembrane protein 267.	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	0.558
WDR70	HDHD2	ENSP00000265107	ENSP00000300605	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	Haloacid dehalogenase like hydrolase domain containing 2.	0.480
WDR70	NADK2	ENSP00000265107	ENSP00000371362	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	0.475
WDR70	TMEM267	ENSP00000265107	ENSP00000426067	WD repeat domain 70; Belongs to the WD repeat GAD-1 family.	Transmembrane protein 267.	0.558