node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AK9 | ANKAR | ENSP00000410186 | ENSP00000427882 | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | Ankyrin and armadillo repeat containing. | 0.467 |
ANKAR | AK9 | ENSP00000427882 | ENSP00000410186 | Ankyrin and armadillo repeat containing. | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | 0.467 |
ANKAR | DIRC1 | ENSP00000427882 | ENSP00000307860 | Ankyrin and armadillo repeat containing. | Disrupted in renal carcinoma 1. | 0.507 |
ANKAR | IGFALS | ENSP00000427882 | ENSP00000416683 | Ankyrin and armadillo repeat containing. | Insulin-like growth factor-binding protein complex acid labile subunit; Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. | 0.510 |
ANKAR | NEMP2 | ENSP00000427882 | ENSP00000386292 | Ankyrin and armadillo repeat containing. | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | 0.675 |
ANKAR | ORMDL1 | ENSP00000427882 | ENSP00000326869 | Ankyrin and armadillo repeat containing. | ORM1-like protein 1; Negative regulator of sphingolipid synthesis. | 0.614 |
ANKAR | OSGEPL1 | ENSP00000427882 | ENSP00000264151 | Ankyrin and armadillo repeat containing. | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.932 |
ANKAR | PMS1 | ENSP00000427882 | ENSP00000406490 | Ankyrin and armadillo repeat containing. | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA. | 0.490 |
ANKAR | TMF1 | ENSP00000427882 | ENSP00000494067 | Ankyrin and armadillo repeat containing. | TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). | 0.820 |
ANKAR | USF3 | ENSP00000427882 | ENSP00000320794 | Ankyrin and armadillo repeat containing. | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. | 0.480 |
ANKAR | WDR75 | ENSP00000427882 | ENSP00000314193 | Ankyrin and armadillo repeat containing. | WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. | 0.523 |
DIRC1 | ANKAR | ENSP00000307860 | ENSP00000427882 | Disrupted in renal carcinoma 1. | Ankyrin and armadillo repeat containing. | 0.507 |
DIRC1 | NEMP2 | ENSP00000307860 | ENSP00000386292 | Disrupted in renal carcinoma 1. | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | 0.526 |
IGFALS | ANKAR | ENSP00000416683 | ENSP00000427882 | Insulin-like growth factor-binding protein complex acid labile subunit; Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. | Ankyrin and armadillo repeat containing. | 0.510 |
NEMP2 | ANKAR | ENSP00000386292 | ENSP00000427882 | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | Ankyrin and armadillo repeat containing. | 0.675 |
NEMP2 | DIRC1 | ENSP00000386292 | ENSP00000307860 | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | Disrupted in renal carcinoma 1. | 0.526 |
NEMP2 | ORMDL1 | ENSP00000386292 | ENSP00000326869 | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | ORM1-like protein 1; Negative regulator of sphingolipid synthesis. | 0.479 |
NEMP2 | OSGEPL1 | ENSP00000386292 | ENSP00000264151 | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.565 |
ORMDL1 | ANKAR | ENSP00000326869 | ENSP00000427882 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis. | Ankyrin and armadillo repeat containing. | 0.614 |
ORMDL1 | NEMP2 | ENSP00000326869 | ENSP00000386292 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis. | Nuclear envelope integral membrane protein 2; Belongs to the NEMP family. | 0.479 |