SERPINE3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD29	FAM124A	ENSP00000468354	ENSP00000280057	Ankyrin repeat domain 29.	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.	0.421
ANKRD29	SERPINE3	ENSP00000468354	ENSP00000428316	Ankyrin repeat domain 29.	Serpin E3; Probable serine protease inhibitor.	0.454
ANKRD29	WDFY2	ENSP00000468354	ENSP00000298125	Ankyrin repeat domain 29.	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti- adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By si [...]	0.404
FAM124A	ANKRD29	ENSP00000280057	ENSP00000468354	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.	Ankyrin repeat domain 29.	0.421
FAM124A	SERPINE3	ENSP00000280057	ENSP00000428316	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.	Serpin E3; Probable serine protease inhibitor.	0.512
FAM124A	WDFY2	ENSP00000280057	ENSP00000298125	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti- adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By si [...]	0.440
HMSD	SERPINE3	ENSP00000386207	ENSP00000428316	Serpin-like protein HMSD; Putative serine protease inhibitor.	Serpin E3; Probable serine protease inhibitor.	0.480
INTS6	SERPINE3	ENSP00000310260	ENSP00000428316	Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.	Serpin E3; Probable serine protease inhibitor.	0.631
INTS6	WDFY2	ENSP00000310260	ENSP00000298125	Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti- adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By si [...]	0.485
LACTBL1	LRIT2	ENSP00000402297	ENSP00000438264	Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.	Leucine rich repeat, Ig-like and transmembrane domains 2.	0.587
LACTBL1	SAPCD1	ENSP00000402297	ENSP00000411948	Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.	Suppressor APC domain containing 1.	0.469
LACTBL1	SERPINE3	ENSP00000402297	ENSP00000428316	Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.	Serpin E3; Probable serine protease inhibitor.	0.426
LRIT2	LACTBL1	ENSP00000438264	ENSP00000402297	Leucine rich repeat, Ig-like and transmembrane domains 2.	Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.	0.587
LRIT2	SAPCD1	ENSP00000438264	ENSP00000411948	Leucine rich repeat, Ig-like and transmembrane domains 2.	Suppressor APC domain containing 1.	0.569
LRIT2	SERPINE3	ENSP00000438264	ENSP00000428316	Leucine rich repeat, Ig-like and transmembrane domains 2.	Serpin E3; Probable serine protease inhibitor.	0.505
SAPCD1	LACTBL1	ENSP00000411948	ENSP00000402297	Suppressor APC domain containing 1.	Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.	0.469
SAPCD1	LRIT2	ENSP00000411948	ENSP00000438264	Suppressor APC domain containing 1.	Leucine rich repeat, Ig-like and transmembrane domains 2.	0.569
SAPCD1	SERPINE3	ENSP00000411948	ENSP00000428316	Suppressor APC domain containing 1.	Serpin E3; Probable serine protease inhibitor.	0.488
SERPINE3	ANKRD29	ENSP00000428316	ENSP00000468354	Serpin E3; Probable serine protease inhibitor.	Ankyrin repeat domain 29.	0.454
SERPINE3	FAM124A	ENSP00000428316	ENSP00000280057	Serpin E3; Probable serine protease inhibitor.	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.	0.512