| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD274 | METTL3 | ENSP00000370989 | ENSP00000298717 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays [...] | 0.493 |
| CD274 | TMEM200B | ENSP00000370989 | ENSP00000428544 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Transmembrane protein 200B. | 0.470 |
| CITED4 | TMEM200B | ENSP00000361721 | ENSP00000428544 | Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Belongs to the CITED family. | Transmembrane protein 200B. | 0.436 |
| CWH43 | TMEM200B | ENSP00000226432 | ENSP00000428544 | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. | Transmembrane protein 200B. | 0.408 |
| METTL3 | CD274 | ENSP00000298717 | ENSP00000370989 | N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays [...] | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.493 |
| METTL3 | TMEM200B | ENSP00000298717 | ENSP00000428544 | N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays [...] | Transmembrane protein 200B. | 0.470 |
| TAGLN | TMEM200B | ENSP00000376678 | ENSP00000428544 | Transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence; Belongs to the calponin family. | Transmembrane protein 200B. | 0.490 |
| TMEM200B | CD274 | ENSP00000428544 | ENSP00000370989 | Transmembrane protein 200B. | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.470 |
| TMEM200B | CITED4 | ENSP00000428544 | ENSP00000361721 | Transmembrane protein 200B. | Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Belongs to the CITED family. | 0.436 |
| TMEM200B | CWH43 | ENSP00000428544 | ENSP00000226432 | Transmembrane protein 200B. | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. | 0.408 |
| TMEM200B | METTL3 | ENSP00000428544 | ENSP00000298717 | Transmembrane protein 200B. | N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core. N6- methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays [...] | 0.470 |
| TMEM200B | TAGLN | ENSP00000428544 | ENSP00000376678 | Transmembrane protein 200B. | Transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence; Belongs to the calponin family. | 0.490 |
| TMEM200B | ZBTB39 | ENSP00000428544 | ENSP00000300101 | Transmembrane protein 200B. | Zinc finger and BTB domain-containing protein 39; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.402 |
| ZBTB39 | TMEM200B | ENSP00000300101 | ENSP00000428544 | Zinc finger and BTB domain-containing protein 39; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transmembrane protein 200B. | 0.402 |
