node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD163L1 | TMEM200B | ENSP00000393474 | ENSP00000428544 | Scavenger receptor cysteine-rich type 1 protein M160; CD163 molecule like 1. | Transmembrane protein 200B. | 0.406 |
CD274 | MTUS1 | ENSP00000370989 | ENSP00000262102 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. | 0.909 |
CD274 | MTUS2 | ENSP00000370989 | ENSP00000498251 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. In the C-terminal section; belongs to the MTUS1 family. | 0.909 |
CD274 | TMEM200B | ENSP00000370989 | ENSP00000428544 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Transmembrane protein 200B. | 0.447 |
CITED4 | TMEM200B | ENSP00000361721 | ENSP00000428544 | Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Belongs to the CITED family. | Transmembrane protein 200B. | 0.436 |
KIAA0895 | TMEM200B | ENSP00000297063 | ENSP00000428544 | Uncharacterized protein KIAA0895; KIAA0895. | Transmembrane protein 200B. | 0.417 |
MTUS1 | CD274 | ENSP00000262102 | ENSP00000370989 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.909 |
MTUS1 | TMEM200B | ENSP00000262102 | ENSP00000428544 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. | Transmembrane protein 200B. | 0.541 |
MTUS2 | CD274 | ENSP00000498251 | ENSP00000370989 | Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. In the C-terminal section; belongs to the MTUS1 family. | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.909 |
MTUS2 | TMEM200B | ENSP00000498251 | ENSP00000428544 | Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. In the C-terminal section; belongs to the MTUS1 family. | Transmembrane protein 200B. | 0.542 |
TMEM200B | CD163L1 | ENSP00000428544 | ENSP00000393474 | Transmembrane protein 200B. | Scavenger receptor cysteine-rich type 1 protein M160; CD163 molecule like 1. | 0.406 |
TMEM200B | CD274 | ENSP00000428544 | ENSP00000370989 | Transmembrane protein 200B. | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.447 |
TMEM200B | CITED4 | ENSP00000428544 | ENSP00000361721 | Transmembrane protein 200B. | Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Belongs to the CITED family. | 0.436 |
TMEM200B | KIAA0895 | ENSP00000428544 | ENSP00000297063 | Transmembrane protein 200B. | Uncharacterized protein KIAA0895; KIAA0895. | 0.417 |
TMEM200B | MTUS1 | ENSP00000428544 | ENSP00000262102 | Transmembrane protein 200B. | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. | 0.541 |
TMEM200B | MTUS2 | ENSP00000428544 | ENSP00000498251 | Transmembrane protein 200B. | Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. In the C-terminal section; belongs to the MTUS1 family. | 0.542 |